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407318 β-Interferon, Human, Recombinant, CHO Cells

β-Interferon, Human, Recombinant, CHO Cells MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Interferon α-2 precursor, IFN-β-1a, rHuIFN-β-1a

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407318
  
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      Overview

      Replacement Information
      Description
      Overview

      This product has been discontinued.



      Recombinant, human interferon-β (IFN-β) expressed in CHO cells as a single glycosylated polypeptide containing 166 amino acids. Purified by chromatographic methods. IFN-β is a type I cytokine produced in response to exposure to viruses or double-stranded RNAs. It is also induced by other cytokines, such as TNF and IL-1. It is involved in the regulation of non-specific humoral immune responses and immune responses to viral infections, and thus exhibits anti-viral, anti-proliferative, and immunomodulating properties. The biological activity of IFN-β, unlike IFN-α, is strictly species-specific and will not be active across species.
      Catalogue Number407318
      Brand Family Calbiochem®
      SynonymsInterferon α-2 precursor, IFN-β-1a, rHuIFN-β-1a
      References
      ReferencesGoebel, M.U., et al. 2005. Physiol. Behav. 84, 807.
      Graber, J., et al. 2005. J. Neuroimmunol. 161,169.
      Mallada-Frechin, J., et al. 2005. Rev. Neurol. 40, 482.
      Patten, S.B., et al. 2005. Mult. Scler. 11, 175.
      Pohl, D., et al. 2005. Neurology 64, 888.
      Schwid, S.R., et al. 2005. Arch. Neurol. 62, 785.
      Product Information
      FormLyophilized
      FormulationLyophilized from 62 mg/ml mannitol, 9.1 mg/ml human albumin, 0.9 mg/ml acetate, pH 7.0-7.2.
      Quality LevelMQ100
      Applications
      Biological Information
      Biological activityReported as IU/mg on a lot-specific basis using a viral resistance assay
      Purity≥98% by SDS-PAGE
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Blue Ice Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Moisture Protect from moisture
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, refrigerate (4°C) for short-term storage or aliquot and freeze (-20°C) for long-term storage. Stock solutions are stable for up to 7 days at 4°C or for up to 4 months at -20°C. Avoid freeze/thaw cycles of solutions.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      407318 0

      Documentation

      β-Interferon, Human, Recombinant, CHO Cells SDS

      Title

      Safety Data Sheet (SDS) 

      β-Interferon, Human, Recombinant, CHO Cells Certificates of Analysis

      TitleLot Number
      407318

      References

      Reference overview
      Goebel, M.U., et al. 2005. Physiol. Behav. 84, 807.
      Graber, J., et al. 2005. J. Neuroimmunol. 161,169.
      Mallada-Frechin, J., et al. 2005. Rev. Neurol. 40, 482.
      Patten, S.B., et al. 2005. Mult. Scler. 11, 175.
      Pohl, D., et al. 2005. Neurology 64, 888.
      Schwid, S.R., et al. 2005. Arch. Neurol. 62, 785.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision14-May-2009 JSW
      SynonymsInterferon α-2 precursor, IFN-β-1a, rHuIFN-β-1a
      DescriptionRecombinant, human interferon-β (IFN-β) expressed in CHO cells as a single glycosylated polypeptide containing 166 amino acids. Purified by chromatographic methods. IFN-β is a type I cytokine produced in response to exposure to viruses or double-stranded RNAs. It is also induced by other cytokines, such as TNF and IL-1. It is involved in the regulation of non-specific humoral immune responses and immune responses to viral infections, and thus exhibits anti-viral, anti-proliferative, and immunomodulating properties. The biological activity of IFN-β, unlike IFN-α, is strictly species-specific and will not be active across species.
      FormLyophilized
      FormulationLyophilized from 62 mg/ml mannitol, 9.1 mg/ml human albumin, 0.9 mg/ml acetate, pH 7.0-7.2.
      Purity≥98% by SDS-PAGE
      Biological activityReported as IU/mg on a lot-specific basis using a viral resistance assay
      SolubilityReconstitute with sterile water to ≥100 µg/ml, containing 0.1% HSA or BSA. Further dilute with aqueous buffer just prior to use.
      Storage Protect from moisture
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, refrigerate (4°C) for short-term storage or aliquot and freeze (-20°C) for long-term storage. Stock solutions are stable for up to 7 days at 4°C or for up to 4 months at -20°C. Avoid freeze/thaw cycles of solutions.
      Toxicity Standard Handling
      ReferencesGoebel, M.U., et al. 2005. Physiol. Behav. 84, 807.
      Graber, J., et al. 2005. J. Neuroimmunol. 161,169.
      Mallada-Frechin, J., et al. 2005. Rev. Neurol. 40, 482.
      Patten, S.B., et al. 2005. Mult. Scler. 11, 175.
      Pohl, D., et al. 2005. Neurology 64, 888.
      Schwid, S.R., et al. 2005. Arch. Neurol. 62, 785.