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376820 β-Hexosaminidase Inhibitor - CAS 281224-40-6 - Calbiochem

The β-Hexosaminidase Inhibitor, also referenced under CAS 281224-40-6, controls the biological activity of β-Hexosaminidase. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: M-31850

376820
  
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      Overview

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      281224-40-6C₂₈H₂₁N₃O₄ • 1/2(CH₃OH)
      Description
      Overview

      This product has been discontinued.



      A cell-permeable bisnaphthalimide compound that acts as a substrate-competitive and selective inhibitor against human β-N-acetyl hexosaminidase (IC50 = 6.0 and 3.1 µM for hHex A and hHex B, respectively), while exhibiting much reduced potency against Jack Bean or bacterial Hex (IC50 = 280 & >500 µM for JBHex & SpHex, respectively) and little or no activity against SmHex or hOGN. Shown to function as a pharmacological chaperone and effectively enhance the transport of mutant Hex alpha subunit from the ER to lysosome in cells derived from ISD and ATSD patients.
      Catalogue Number376820
      Brand Family Calbiochem®
      SynonymsM-31850
      References
      ReferencesTropak, M.B., et al. 2007. Chem. Biol. 14, 153.
      Product Information
      CAS number281224-40-6
      FormWhite solid
      Hill FormulaC₂₈H₂₁N₃O₄ • 1/2(CH₃OH)
      Chemical formulaC₂₈H₂₁N₃O₄ • 1/2(CH₃OH)
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at 20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      376820 0

      Documentation

      β-Hexosaminidase Inhibitor - CAS 281224-40-6 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      β-Hexosaminidase Inhibitor - CAS 281224-40-6 - Calbiochem Certificates of Analysis

      TitleLot Number
      376820

      References

      Reference overview
      Tropak, M.B., et al. 2007. Chem. Biol. 14, 153.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision12-April-2011 RFH
      SynonymsM-31850
      DescriptionA cell-permeable bisnaphthalimide compound that acts as a substrate-competitive and selective inhibitor against human β-N-acetyl hexosaminidase (IC50 = 6.0 & 3.1 µM for hHex A & hHex B, respectively), while exhibiting much reduced potency against Jack Bean or bacterial Hex (IC50 = 280 & >500 µM for JBHex & SpHex, respectively) and little or no activity against SmHex or hOGN. Shown to function as a pharmacological chaperone and effectively enhance the transport of mutant Hex alpha subunit from the ER to lysosome in cells derived from ISD and ATSD patients.
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      Recommended reaction conditions
      Please Note: DMSO is known to exhibit inhibitory effects against hexosaminidase, therefore it is essential to include proper vehicle controls if a hexosaminidase inhibitor stock prepared in DMSO is used in studies involving hexosaminidase.
      CAS number281224-40-6
      Chemical formulaC₂₈H₂₁N₃O₄ • 1/2(CH₃OH)
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (1 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at 20°C.
      Toxicity Standard Handling
      ReferencesTropak, M.B., et al. 2007. Chem. Biol. 14, 153.