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506163 p38 MAP Kinase Inhibitor VIII - CAS 321351-00-2 - Calbiochem

The p38 MAP Kinase Inhibitor VIII, also referenced under CAS 321351-00-2, controls the biological activity of p38 MAP Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: (4-((2-Amino-4-bromophenyl)amino)-2-chlorophenyl)-(2-methylphenyl)methanone

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506163
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
321351-00-2C₂₀H₁₆BrClN₂O

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506163-5MG
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      		 Plastic ampoule 5 mg
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      Description
      OverviewA cell-permeable aminobenzophenone compound that acts as a potent, ATP-binding pocket-targeting inhibitor against p38α and p38β2 (82% and 93% inhibition with 1 µM inhibitor, respectively; IC50 of p38α inhibition = 40 nM) with little activity against a panel of 57 other kinases, including p38γ, p38δ, Erk1/2, and JNK1. Shown to inhibit LPS-induced cytokine productions in human PBMC's in vitro and exhibit in vivo efficacy in both acute and chronic murine models of skin inflammation.
      Catalogue Number506163
      Brand Family Calbiochem®
      Synonyms(4-((2-Amino-4-bromophenyl)amino)-2-chlorophenyl)-(2-methylphenyl)methanone
      References
      ReferencesOttosen, E.R., et al. 2003. J. Med. Chem. 46, 5651.
      Product Information
      CAS number321351-00-2
      FormYellow solid
      Hill FormulaC₂₀H₁₆BrClN₂O
      Chemical formulaC₂₀H₁₆BrClN₂O
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥97% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      S PhraseS: 22-24/25-36/37/39-45

      Do not breathe dust.
      Avoid contact with skin and eyes.
      Wear suitable protective clothing, gloves and eye/face protection.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      506163-5MG 04055977272307

      Documentation

      p38 MAP Kinase Inhibitor VIII - CAS 321351-00-2 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      p38 MAP Kinase Inhibitor VIII - CAS 321351-00-2 - Calbiochem Certificates of Analysis

      TitleLot Number
      506163

      References

      Reference overview
      Ottosen, E.R., et al. 2003. J. Med. Chem. 46, 5651.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision15-April-2009 RFH
      Synonyms(4-((2-Amino-4-bromophenyl)amino)-2-chlorophenyl)-(2-methylphenyl)methanone
      DescriptionA cell-permeable aminobenzophenone compound that acts as a potent, ATP-binding pocket-targeting inhibitor against p38α and p38β2 (82% and 93% inhibition with 1 µM inhibitor, respectively; IC50 of p38α inhibition = 40 nM) with little activity against a panel of 57 other kinases, including p38γ, p38δ, Erk1/2, and JNK1. Shown to inhibit LPS-induced cytokine productions in human PBMC's in vitro and exhibit in vivo efficacy in both acute and chronic murine models of skin inflammation.
      FormYellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number321351-00-2
      Chemical formulaC₂₀H₁₆BrClN₂O
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityDMSO (50 mg/ml) or Ethanol (15 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesOttosen, E.R., et al. 2003. J. Med. Chem. 46, 5651.