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676380 Valproic Acid, Sodium Salt - CAS 1069-66-5 - Calbiochem

Valproic Acid, Sodium Salt, CAS 1069-66-5, is a cell-permeable inhibitor of histone deacetylase (IC50 = 400 µM for HDAC1). Inhibits proliferation of human malignant glioma cell lines.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 2-Propylpentanoic Acid, Na

Primary Target: HDAC1
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676380
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
1069-66-5C₈H₁₅O₂Na

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      Description
      OverviewA cell-permeable, short-chained fatty acid that inhibits histone deacetylase (IC50 = 400 µM for HDAC1). Induces differentiation and inhibits proliferation of cell lines derived from human malignant gliomas. At therapeutic levels (0.35 mM - 1.04 mM), causes inositol depletion, inhibits both GSK-3α and -3β, activates ERK pathway and produces neurotropic effects. Has been used as an anti-epileptic agent. Also reported to stimulate peroxisome proliferator-activated receptor (PPAR) activity. Displays a potent teratogenic activity in humans and rodent models.
      Catalogue Number676380
      Brand Family Calbiochem®
      Synonyms2-Propylpentanoic Acid, Na
      References
      ReferencesGottlicher, M., et al. 2001. EMBO J. 20, 6969.
      Knupfer, M.M., et al. 2001. Anticancer Res. 21, 347.
      Phiel, C.J., et al. 2001. J. Biol. Chem. 276, 36734.
      Vaden, D.L., et al. 2001. J. Biol. Chem. 276, 15466.
      Yuan, P.X., et al. 2001. J. Biol. Chem. 276, 31674.
      Chen, G., et al. 1999. J. Neurochem. 72, 1327.
      Product Information
      CAS number1069-66-5
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₈H₁₅O₂Na
      Chemical formulaC₈H₁₅O₂Na
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationValproic Acid, Sodium Salt, CAS 1069-66-5, is a cell-permeable inhibitor of histone deacetylase (IC50 = 400 µM for HDAC1). Inhibits proliferation of human malignant glioma cell lines.
      Biological Information
      Primary TargetHDAC1
      Primary Target IC<sub>50</sub>400 µM
      Purity≥98% by GC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSYV7876000
      Safety Information
      R PhraseR: 20/21/22-36/37/38-61

      Harmful by inhalation, in contact with skin and if swallowed.
      Irritating to eyes, respiratory system and skin.
      May cause harm to the unborn child.
      S PhraseS: 3/7/9-22-36/37/39-45

      Keep container tightly closed, in a cool well ventilated place.
      Do not breathe dust.
      Wear suitable protective clothing, gloves and eye/face protection.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful & Carcinogenic / Teratogenic
      Storage +2°C to +8°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      676380-5GM 04055977183566

      Documentation

      Required Licenses

      Title
      PRODUCTO REGULADO POR LA SECRETARÍA DE SALUD

      Valproic Acid, Sodium Salt - CAS 1069-66-5 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Valproic Acid, Sodium Salt - CAS 1069-66-5 - Calbiochem Certificates of Analysis

      TitleLot Number
      676380

      References

      Reference overview
      Gottlicher, M., et al. 2001. EMBO J. 20, 6969.
      Knupfer, M.M., et al. 2001. Anticancer Res. 21, 347.
      Phiel, C.J., et al. 2001. J. Biol. Chem. 276, 36734.
      Vaden, D.L., et al. 2001. J. Biol. Chem. 276, 15466.
      Yuan, P.X., et al. 2001. J. Biol. Chem. 276, 31674.
      Chen, G., et al. 1999. J. Neurochem. 72, 1327.

      Technical Info

      Title
      White Paper - The Message in the Marks: Deciphering Cancer Epigenetics

      Data Sheet

      Title
      Reprogramming Cell Fate and Function Novel Strategies for iPSC Generation, Characterization, and Differentiation
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision27-April-2020 JSW
      Synonyms2-Propylpentanoic Acid, Na
      DescriptionA cell-permeable, short-chained fatty acid that inhibits histone deacetylase activity (IC50 = 400 µM for HDAC1). Induces differentiation and inhibits proliferation of cell lines derived from human malignant gliomas. At therapeutic levels (350 µM-1.04 mM), causes inositol depletion, inhibits both GSK-3α and -3β, activates the ERK pathway, and produces neurotropic effects. Has been used as an anti-epileptic agent. Also reported to stimulate peroxisome proliferator-activated receptor (PPAR) activity. Displays a potent teratogenic activity in humans and rodent models.
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number1069-66-5
      RTECSYV7876000
      Chemical formulaC₈H₁₅O₂Na
      Structure formulaStructure formula
      Purity≥98% by GC
      SolubilityH₂O (50 mg/ml)
      Storage +2°C to +8°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Harmful & Carcinogenic / Teratogenic
      Merck USA index14, 9913
      ReferencesGottlicher, M., et al. 2001. EMBO J. 20, 6969.
      Knupfer, M.M., et al. 2001. Anticancer Res. 21, 347.
      Phiel, C.J., et al. 2001. J. Biol. Chem. 276, 36734.
      Vaden, D.L., et al. 2001. J. Biol. Chem. 276, 15466.
      Yuan, P.X., et al. 2001. J. Biol. Chem. 276, 31674.
      Chen, G., et al. 1999. J. Neurochem. 72, 1327.