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14-739M TLK2 Protein, active, 250 µg

Active, N-terminal 6His-tagged, recombinant, 388-end, human TLK2. For use in Kinase Assays.

TLK2 Protein, active, 250 µg MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
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14-739M
250 µg  Also available in 10 μg size (cat#14-739) and in bulk (cat# 14-739-K).
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      Overview

      Replacement Information
      Description
      Catalogue Number14-739M
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionTLK2 Protein, active, 250 µg
      OverviewN-terminal 6His-tagged, recombinant, 388-end, human TLK2.
      Alternate Names
      • tousled-like kinase 2
      References
      Product Information
      Quality LevelMQ100
      Applications
      ApplicationActive, N-terminal 6His-tagged, recombinant, 388-end, human TLK2. For use in Kinase Assays.
      Key Applications
      • Kinase Assay
      Biological Information
      SourceExpressed by baculovirus in Sf21 cells.
      Specific ActivityFor Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
      Entrez Gene Number
      Entrez Gene SummaryThe Tousled-like kinases, first described in Arabidopsis, are nuclear serine/threonine kinases that are potentially involved in the regulation of chromatin assembly.[supplied by OMIM]
      Gene Symbol
      • TLK2
      • MGC44450
      • PKU-alpha
      • PKU-ALPHA
      Protein TargetTLK2
      Purification MethodNi2+/NTA-agarose
      Target Sub-FamilyMisc
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q86UE8 # Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S- phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly.
      COFACTOR: Magnesium.
      SIZE: 772 amino acids; 87661 Da
      SUBUNIT: Heterodimerizes with TLK1. Interacts with ASF1A and ASF1B.
      SUBCELLULAR LOCATION: Nucleus.
      TISSUE SPECIFICITY: Widely expressed. Present in fetal placenta, liver, kidney, pancreas, heart and skeletal muscle. Also found in adult cell lines.
      SIMILARITY: SwissProt: Q86UE8 ## Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. & Contains 1 protein kinase domain.
      Molecular Weight48.8 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 6 months at -70°C from date of shipment. For maximum recovery of product, centrifuge original vial prior to removing the cap.
      Rapidly thaw the vial under cold water and immediately place on ice. Aliquot unused material into pre-chilled microcentrifuge tubes and immediately snap-freeze the vials in liquid nitrogen prior to re-storage at -70°C.
      Packaging Information
      Material Size250 µg
      Material PackageAlso available in 10 μg size (cat#14-739) and in bulk (cat# 14-739-K).
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      14-739M 04053252411915

      Related Products & Applications

      Alternative Packsize

      Catalogue Number Description  
      14-739 TLK2 Protein, active, 10 µg Show Pricing & Availability

      Product Families

      Kinase & Phosphatase Products

      Millipore offers a large portfolio of Kinases, Phophatases, Substrates, Inhibitors, Kits, reagents & tools for Signaling research. See below for a list of these products, in multiple pack sizes.
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      Categories

      Life Science Research > Proteins and Enzymes > Purified Kinases
      Life Science Research > Drug Discovery and Development > Kinase & Phosphatase Screening > Purified Kinases