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574713 Syk Inhibitor III - CAS 1485-00-3 - Calbiochem

The Syk Inhibitor III, also referenced under CAS 1485-00-3, controls the biological activity of Syk. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 3,4-Methylenedioxy-β-nitrostyrene

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574713
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574713-50MG
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      Description
      OverviewA cell-permeable nitrostyrene compound that acts as a selective inhibitor of Syk kinase activity (IC50 = 2.5 µM). It inhibits Src only at much higher concentrations (IC50 = 29.3 µM) and exhibits little effect against Fak and JAK2. Shown to potently inhibit platelet aggregation induced by various stimulators, including U46619, ADP, arachidonic acid, collagen, thrombin, ionophore A23187, and PDBu (IC50 ranges from 2.1 to 25.9 µM).
      Catalogue Number574713
      Brand Family Calbiochem®
      Synonyms3,4-Methylenedioxy-β-nitrostyrene
      References
      ReferencesWang, W.Y., et al. 2006. Mol. Pharmacol. 70, 1380.
      Product Information
      CAS number1485-00-3
      ATP CompetitiveN
      FormYellow to brown solid
      Hill FormulaC₉H₇NO₄
      Chemical formulaC₉H₇NO₄
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetSyk
      Primary Target IC<sub>50</sub>2.5 µM against Syk kinase activity
      Purity≥98% by GC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSWL5270000
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Irritant
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      574713-50MG 04055977189681

      Documentation

      Required Licenses

      Title
      PRODUCTO REGULADO POR LA SECRETARÍA DE SALUD

      Syk Inhibitor III - CAS 1485-00-3 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Syk Inhibitor III - CAS 1485-00-3 - Calbiochem Certificates of Analysis

      TitleLot Number
      574713

      References

      Reference overview
      Wang, W.Y., et al. 2006. Mol. Pharmacol. 70, 1380.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision29-April-2016 JSW
      Synonyms3,4-Methylenedioxy-β-nitrostyrene
      DescriptionA cell-permeable nitrostyrene compound that acts as a selective inhibitor of Syk kinase activity (IC50 = 2.5 µM). It inhibits Src only at much higher concentrations (IC50 = 29.3 µM) and exhibits little effect against Fak and JAK2. Shown to potently inhibit platelet aggregation induced by various stimulators, including U46619, ADP, arachidonic acid, collagen, thrombin, ionophore A23187, and PDBu (IC50 ranges from 2.1 to 25.9 µM).
      FormYellow to brown solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number1485-00-3
      RTECSWL5270000
      Chemical formulaC₉H₇NO₄
      Structure formulaStructure formula
      Purity≥98% by GC
      SolubilityDMSO (25 mg/ml). Use only fresh DMSO.
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Irritant
      ReferencesWang, W.Y., et al. 2006. Mol. Pharmacol. 70, 1380.