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566331 SIRT2 Inhibitor II, AK-1 - CAS 330461-64-8 - Calbiochem

The SIRT2 Inhibitor II, AK-1, also referenced under CAS 330461-64-8, controls the biological activity of SIRT2. This small molecule/inhibitor is primarily used for Cell Structure applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 3-(azepan-1-ylsulfonyl)-N-(3-nitrophenyl)benzamide, SIRT2 Inhibitor II, AK-1

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566331
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
330461-64-8C₁₉H₂₁N₃O₅S

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566331-10MG
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      Description
      OverviewA cell permeable, benzylsulfonamide that inhibits SIRT2 activity (IC50= 12.5 µM through enzymatic assay) by targeting the SIRT2 nicotinamide binding site, but may also target SIRT1 and SIRT3 (IC50 >40 µM) with much less potency. Western analysis illustrates that treatment with AK-1 (> 25 µM) leads to an increase in acetylated tubulin. AK-1 (1 to 10 µM) is shown to rescue neuronal dysfunction in two in vivo models of Huntington's Disease (HD) in Dropshila and Caenorhabditis elegans. It also demonstrates recovery of neuronal toxicity in a primary model of HD from 1µM to 4 µM similar to that of genetic SIRT2 inhibition, and also correlates with the negative regulation of sterol biosynthesis.
      Catalogue Number566331
      Brand Family Calbiochem®
      Synonyms3-(azepan-1-ylsulfonyl)-N-(3-nitrophenyl)benzamide, SIRT2 Inhibitor II, AK-1
      References
      ReferencesLuthi-Carter, R., et al. 2010. Proc. Natl. Acad. Sci. 107, 7927.
      Outeiro, TF., et al. 2007. Science 317, 516.
      Product Information
      CAS number330461-64-8
      FormOff-white solid
      Hill FormulaC₁₉H₂₁N₃O₅S
      Chemical formulaC₁₉H₂₁N₃O₅S
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity>95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      566331-10MG 04055977191479

      Documentation

      SIRT2 Inhibitor II, AK-1 - CAS 330461-64-8 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      SIRT2 Inhibitor II, AK-1 - CAS 330461-64-8 - Calbiochem Certificates of Analysis

      TitleLot Number
      566331

      References

      Reference overview
      Luthi-Carter, R., et al. 2010. Proc. Natl. Acad. Sci. 107, 7927.
      Outeiro, TF., et al. 2007. Science 317, 516.

      Data Sheet

      Title
      SIRTainty™ Class III HDAC Assay
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision13-December-2013 JSW
      Synonyms3-(azepan-1-ylsulfonyl)-N-(3-nitrophenyl)benzamide, SIRT2 Inhibitor II, AK-1
      DescriptionA cell permeable, benzylsulfonamide that inhibits SIRT2 activity (IC50= 12.5 µM through enzymatic assay) by targeting the SIRT2 nicotinamide binding site, but may also target SIRT1 and SIRT3 (IC50 >40 µM) with much less potency. Western analysis illustrates that treatment with AK-1 (> 25 µM) leads to an increase in acetylated tubulin. AK-1 (1 to 10 µM) is shown to rescue neuronal dysfunction in two in vivo models of Huntington's Disease (HD) in Dropshila and Caenorhabditis elegans. It also demonstrates recovery of neuronal toxicity in a primary model of HD from 1µM to 4 µM similar to that of genetic SIRT2 inhibition, and also correlates with the negative regulation of sterol biosynthesis.
      FormOff-white solid
      CAS number330461-64-8
      Chemical formulaC₁₉H₂₁N₃O₅S
      Structure formulaStructure formula
      Purity>95% by HPLC
      SolubilityDMSO (50 mg/ml)
      Storage +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesLuthi-Carter, R., et al. 2010. Proc. Natl. Acad. Sci. 107, 7927.
      Outeiro, TF., et al. 2007. Science 317, 516.