565835 Sigma-AldrichSHIP1 Inhibitor, 3AC - Calbiochem
SHIP1 Inhibitor, 3AC, CAS 2206-20-4, is a cell-permeable, selective inhibitor of SHIP1 polyphosphatase activity toward PIP3 (IC50 = 10 µM), but has no effect on SHIP2 5′ or PTEN activity on PIP3.
More>> SHIP1 Inhibitor, 3AC, CAS 2206-20-4, is a cell-permeable, selective inhibitor of SHIP1 polyphosphatase activity toward PIP3 (IC50 = 10 µM), but has no effect on SHIP2 5′ or PTEN activity on PIP3. Less<<Synonyms: 3α-Aminocholestane, SH2-domain-containing inositol 5ʹ-phosphatase 1 (SHIP1) Inhibitor, 3AC
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Overview
Key Spec Table
Empirical Formula |
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C₂₇H₄₉N |
Pricing & Availability
Catalogue Number | Availability | Packaging | Qty/Pack | Price | Quantity | |
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565835-10MG |
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Glass bottle | 10 mg |
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Description | |
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Overview | A cell-permeable steroidal compound that selectively inhibits SHIP1′ polyphosphatase activity toward PI(3,4,5)P3 (IC50 = 10 µM), but not SHIP2 5′ or PTEN′ polyphosphatase activity toward PI(3,4,5)P3 (IC50 > 1 mM). Effectively inhibits SHIP1-mediated immune response both in vitro and in vivo, as well as SHIP1-dependent cancer cell survival. SHIP2 Inhibitor, AS1938909 is also available (Cat. No. 565840). |
Catalogue Number | 565835 |
Brand Family | Calbiochem® |
Synonyms | 3α-Aminocholestane, SH2-domain-containing inositol 5ʹ-phosphatase 1 (SHIP1) Inhibitor, 3AC |
References | |
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References | Brooks, R., et al. 2010. J. Immunol. 184, 3582. |
Product Information | |
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Form | White solid |
Hill Formula | C₂₇H₄₉N |
Chemical formula | C₂₇H₄₉N |
Structure formula Image | |
Quality Level | MQ100 |
Biological Information | |
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Purity | ≥98% by 1H NMR |
Packaging Information | |
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Packaged under inert gas | Packaged under inert gas |
Global Trade Item Number | |
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Catalogue Number | GTIN |
565835-10MG | 04055977191929 |