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565835 SHIP1 Inhibitor, 3AC - Calbiochem

Overview

Key Spec Table

Empirical Formula
C₂₇H₄₉N

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565835-10MG
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      Description
      OverviewA cell-permeable steroidal compound that selectively inhibits SHIP1′ polyphosphatase activity toward PI(3,4,5)P3 (IC50 = 10 µM), but not SHIP2 5′ or PTEN′ polyphosphatase activity toward PI(3,4,5)P3 (IC50 > 1 mM). Effectively inhibits SHIP1-mediated immune response both in vitro and in vivo, as well as SHIP1-dependent cancer cell survival. SHIP2 Inhibitor, AS1938909 is also available (Cat. No. 565840).
      Catalogue Number565835
      Brand Family Calbiochem®
      Synonyms3α-Aminocholestane, SH2-domain-containing inositol 5ʹ-phosphatase 1 (SHIP1) Inhibitor, 3AC
      References
      ReferencesBrooks, R., et al. 2010. J. Immunol. 184, 3582.
      Product Information
      FormWhite solid
      Hill FormulaC₂₇H₄₉N
      Chemical formulaC₂₇H₄₉N
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationSHIP1 Inhibitor, 3AC, CAS 2206-20-4, is a cell-permeable, selective inhibitor of SHIP1 polyphosphatase activity toward PIP3 (IC50 = 10 µM), but has no effect on SHIP2 5′ or PTEN activity on PIP3.
      Biological Information
      Purity≥98% by 1H NMR
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      565835-10MG 04055977191929