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521234 PDGFR Tyrosine Kinase Inhibitor V - CAS 347155-76-4 - Calbiochem

The PDGFR Tyrosine Kinase Inhibitor V, also referenced under CAS 347155-76-4, controls the biological activity of PDGFR Tyrosine Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: N-(4-((6,7-Dimethoxy-4-quinoyl)oxy)phenyl)-Nʹ-(2-methylbenzoyl)thiourea, Ki11502

Primary Target: PDGFR
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521234
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
347155-76-4C₂₆H₂₃N₃O₄S • 3H₂O

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      Description
      OverviewA cell-permeable quinolinyl-thiourea compound that acts a potent, ATP-competitive, and reversible inhibitor of PDGFR (IC50 = 4 and 7.6 nM in ligand-induced cellular PDGFR phosphorylation and in in vitro kinase activity, respectively). Inhibits c-kit receptor only at much higher concentrations (IC50 = 434 and 234 nM in receptor phosphorylation and kinase activity, respectively). Shown to potently inhibit neointima formation in a rat carotid artery balloon injury model in vivo (30 mg/kg, p.o.).
      Catalogue Number521234
      Brand Family Calbiochem®
      SynonymsN-(4-((6,7-Dimethoxy-4-quinoyl)oxy)phenyl)-Nʹ-(2-methylbenzoyl)thiourea, Ki11502
      References
      ReferencesGetachew, R., et al. 2009. Eur. J. Pharmacol.<→i> In press.
      Nishioka, C., et al. 2008. Blood 111, 5086.
      Furuta, T., et al. 2006. J. Med. Chem. 49, 2186.
      Product Information
      CAS number347155-76-4
      ATP CompetitiveY
      FormOff-white solid
      Hill FormulaC₂₆H₂₃N₃O₄S • 3H₂O
      Chemical formulaC₂₆H₂₃N₃O₄S • 3H₂O
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetPDGFR
      Primary Target IC<sub>50</sub>4 and 7.6 nM in ligand-induced cellular PDGFR phosphorylation and in in vitro kinase activity, respectively
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Toxic
      Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      521234-1MG 04055977271386

      Documentation

      PDGFR Tyrosine Kinase Inhibitor V - CAS 347155-76-4 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      PDGFR Tyrosine Kinase Inhibitor V - CAS 347155-76-4 - Calbiochem Certificates of Analysis

      TitleLot Number
      521234

      References

      Reference overview
      Getachew, R., et al. 2009. Eur. J. Pharmacol.<→i> In press.
      Nishioka, C., et al. 2008. Blood 111, 5086.
      Furuta, T., et al. 2006. J. Med. Chem. 49, 2186.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision11-November-2009 RFH
      SynonymsN-(4-((6,7-Dimethoxy-4-quinoyl)oxy)phenyl)-Nʹ-(2-methylbenzoyl)thiourea, Ki11502
      DescriptionA cell-permeable quinolinyl-thiourea compound that acts a potent, ATP-competitive, and reversible inhibitor of PDGFR (IC50 = 4 and 7.6 nM in ligand-induced cellular PDGFR phosphorylation and in in vitro kinase activity, respectively). Inhibits c-kit receptor only at much higher concentrations (IC50 = 434 and 234 nM in receptor phosphorylation and kinase activity, respectively). Shown to potently inhibit neointima formation in a rat carotid artery balloon injury model in vivo (30 mg/kg, p.o.).
      FormOff-white solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number347155-76-4
      Chemical formulaC₂₆H₂₃N₃O₄S • 3H₂O
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (25 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Toxic
      ReferencesGetachew, R., et al. 2009. Eur. J. Pharmacol.<→i> In press.
      Nishioka, C., et al. 2008. Blood 111, 5086.
      Furuta, T., et al. 2006. J. Med. Chem. 49, 2186.