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500526 NOX Inhibitor VII, Thr101 - CAS 727664-79-1 - Calbiochem

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: NADPH Oxidase Inhibitor VII, 6-Fluoro-2-o-tolylbenzo[d]isothiazol-3(2H)-one, 6-Fluoro-2-(2-methylphenyl)-1,2-benzothiazol-3(2H)-one

Primary Target: blocks p22phox c-terminal PRD (proline-rich domain) and p47phox bis-SH3 interaction
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500526
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Overview

Key Spec Table

CAS #Empirical Formula
727664-79-1C₁₄H₁₀FNOS

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      		 Glass bottle 25 mg
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      Description
      OverviewA cell-permeable, selenium-to-sulfur substituted Ebselen (Cat. No. 324483) derivative that exhibits similar NOX2 inhibitory activity as Ebselen by blocking p22phox c-terminal PRD (proline-rich domain) and p47phox bis-SH3 interaction. Although less potent than Ebselen in cell-free p22phox PRD-p47phox bis-SH3 binding (IC50 = 4 vs. 0.3 µM) and NOX2 activity (IC50 = 4 vs. 0.6 µM) assays, Thr101 is more potent and NOX2-selective than Ebselen in cell-based assays (Thr101 IC50 /Ebselen IC50 = 0.3/0.5, 3/0.15, 8/no inhibition, 8/0.7 µM, respectively, against NOX2, NOX1, NOX4, and NOX5) and exhibits no glutathione peroxidase activity.

      Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.
      Catalogue Number500526
      Brand Family Calbiochem®
      SynonymsNADPH Oxidase Inhibitor VII, 6-Fluoro-2-o-tolylbenzo[d]isothiazol-3(2H)-one, 6-Fluoro-2-(2-methylphenyl)-1,2-benzothiazol-3(2H)-one
      References
      ReferencesSmith, S.M.E., et al. 2012. Chem. Biol. 19, 752.
      Product Information
      CAS number727664-79-1
      FormLight brown powder
      Hill FormulaC₁₄H₁₀FNOS
      Chemical formulaC₁₄H₁₀FNOS
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Primary Target blocks p22phox c-terminal PRD (proline-rich domain) and p47phox bis-SH3 interaction
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      5.00526.0001 04055977244892