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480418
Sigma-AldrichNF279 - CAS 202983-32-2 - Calbiochem
A suramin analog that acts as a highly selective, competitive, and reversible ATP-antagonist of P2X receptor (IC₅₀/KB ~ 1 µM in smooth muscle).
More>>A suramin analog that acts as a highly selective, competitive, and reversible ATP-antagonist of P2X receptor (IC₅₀/KB ~ 1 µM in smooth muscle). Less<<
NF279 - CAS 202983-32-2 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
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Description
Overview
A suramin analog that acts as a highly selective, competitive, and reversible ATP-antagonist of P2X receptor (IC50/KB ~ 1 µM in smooth muscle). Effectively discriminates between P2Y and P2X receptors with no effect on α1A adrenoceptors, adenosine A1 and A2B receptors, histamine H1, muscarinic M3 and neuronal nicotinic acetylcholine receptors. Displays a selectivity profile of P2X1 >P2X2 >P2X3 >P2X4 (IC50 = 19 nM, 770 nM, 1.62 µM and >300 µM, respectively) in Xenopus oocytes pre-incubated with ATP. In rat and human tissues, exhibits a potency profile of rat P2X1 > human P2X1 > > rat P2X2 > rat P2X3 ~ human P2X7 > > human P2X4. Not degraded by ecto-nucleotidases.
Catalogue Number
480418
Brand Family
Calbiochem®
Synonyms
8,8ʹ-(Carbonylbis(imino-4,1-phenylenecarbonylimino-4,1-phenylenecarbonylimino))bis-1,3,5-naphthalenetrisulfonic Acid, Na
References
References
Klapperstück, M., et al. 2000. Eur. J. Pharmacol.387, 245. Rettinger, J., et al. 2000. Neuropharmacol.39, 2044. Lambrecht, G., et al. 1999. Prog. Brain Res.120,107. Damer, S., et al. 1998. Eur. J. Pharmacol.350, R5.
~ 1 µM as antagonist of P2X receptor in smooth muscle; 19 nM, 770 nM, 1.62 µM and <300 µM, against P2X1, P2X2, P2X3, P2X4, respectively, in Xenopus oocytes pre-incubated with ATP
Purity
≥99% by HPLC
Physicochemical Information
Cell permeable
Y
Storage and Shipping Information
Ship Code
Ambient Temperature Only
Toxicity
Standard Handling
Storage
+2°C to +8°C
Protect from Light
Protect from light
Protect from Moisture
Protect from moisture
Do not freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
NF279 - CAS 202983-32-2 - Calbiochem Certificates of Analysis
Title
Lot Number
480418
References
Reference overview
Klapperstück, M., et al. 2000. Eur. J. Pharmacol.387, 245. Rettinger, J., et al. 2000. Neuropharmacol.39, 2044. Lambrecht, G., et al. 1999. Prog. Brain Res.120,107. Damer, S., et al. 1998. Eur. J. Pharmacol.350, R5.
Data Sheet
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
Revision
11-August-2008 RFH
Synonyms
8,8ʹ-(Carbonylbis(imino-4,1-phenylenecarbonylimino-4,1-phenylenecarbonylimino))bis-1,3,5-naphthalenetrisulfonic Acid, Na
Description
A suramin analog that acts as a highly selective, competitive, and reversible ATP-antagonist of P2X receptor (IC50/KB ~1 µM in smooth muscle). Effectively discriminates between P2Y and P2X receptors with no discernible effects on α1A adrenoceptors, adenosine A1 and A2B receptors, histamine H1, muscarinic M3 and neuronal nicotinic acetylcholine receptors. Displays a selectivity profile of P2X1 >P2X2 >P2X3 >P2X4 (IC50 = 19 nM, 770 nM, 1.62 µM and >300 µM, respectively) in Xenopus oocytes pre-incubated with ATP. In rat and human tissues, exhibits a potency profile of rat P2X1 > human P2X1 » rat P2X2 > rat P2X3 ~human P2X7 » human P2X4. Not degraded by ecto-nucleotidases.
Form
White solid
Intert gas (Yes/No)
Packaged under inert gas
CAS number
202983-32-2
Chemical formula
C₄₉H₃₀N₆O₂₃S₆ · 6Na
Structure formula
Purity
≥99% by HPLC
Solubility
DMSO (14 mg/ml) or H₂O (35 mg/ml)
Storage
Protect from moisture Protect from light +2°C to +8°C
Do Not Freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Toxicity
Standard Handling
References
Klapperstück, M., et al. 2000. Eur. J. Pharmacol.387, 245. Rettinger, J., et al. 2000. Neuropharmacol.39, 2044. Lambrecht, G., et al. 1999. Prog. Brain Res.120,107. Damer, S., et al. 1998. Eur. J. Pharmacol.350, R5.