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376816 Hexokinase II VDAC Binding Domain Peptide, Cell-Permeable - Calbiochem

A cell-permeable peptide analog of Hexokinase II VDAC binding domain peptide.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: HXK2VBD-cpm, H-RQIKIWFQNRRMKWKK-MIASHLLAYFFTELN-NH₂

Primary Target: Detach and translocate HXK2 from mitochondria to the cytosol
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376816
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Overview

Key Spec Table

Empirical Formula
C₁₈₈H₂₉₁N₅₃O₄₀S₂

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376816-1MG
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      Description
      OverviewA cell-permeable peptide analog of Hexokinase II VDAC binding domain peptide (Cat. No. 376815). The internalization domain of the Antennapedia homeoprotein is fused to the methionine amino terminal. Shown to completely detach and translocate HXK2 from mitochondria to the cytosol in HeLa cells at 100 µM. Does not induce Bax translocation or cytochrome c release when used alone. However, it markedly sensitizes cells to cytochrome c release and to the induction of apoptosis when used in combination with a Bax-dependent apoptosis inducer, Indomethacin (Cat. No. 405268).
      Catalogue Number376816
      Brand Family Calbiochem®
      SynonymsHXK2VBD-cpm, H-RQIKIWFQNRRMKWKK-MIASHLLAYFFTELN-NH₂
      References
      ReferencesPastorino, J.G., et al. 2002. J. Biol. Chem. 277, 7610.
      Holinger, E.P., et al. 1999. J. Biol. Chem. 274, 13298.
      Sui, D., and Wilson, J.E. 1997. Arch. Biochem. Biophys. 345, 111.
      Product Information
      ATP CompetitiveN
      FormWhite lyophilized solid
      FormulationSupplied as a trifluoroacetate salt.
      Hill FormulaC₁₈₈H₂₉₁N₅₃O₄₀S₂
      Chemical formulaC₁₈₈H₂₉₁N₅₃O₄₀S₂
      Hygroscopic Hygroscopic
      ReversibleN
      Quality LevelMQ100
      Biological Information
      Primary TargetDetach and translocate HXK2 from mitochondria to the cytosol
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Peptide SequenceH-Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-Met-Ile-Ala-Ser-His-Leu-Leu-Ala-Tyr-Phe-Phe-Thr-Glu-Leu-Asn-NH₂
      Storage and Shipping Information
      Ship Code Blue Ice Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      376816-1MG 04055977212976