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534034 Heterochromatin Inhibitor, HMS-I1 - Calbiochem

A cell-permeable, reversible inhibitor of heterochromatin-mediated gene silencing in mammalian, plant, and fungal cells (5 - 10 µM).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 2-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)-6-methylimidazo[1,2-a]pyridine, 2-(2,3-Dihydro-1,4-benzo[b][1,4]dioxin-6-yl)-6-methylimidazo[1,2-a]pyridine, Heterochromatin Mediated Silencing Inhibitor 1

Primary Target: Clr3-containing Snf2/HDAC repressor complex (SHREC)
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      Overview

      Replacement Information

      Key Spec Table

      Empirical Formula
      C₁₆H₁₄N₂O₂
      Description
      Overview

      This product has been discontinued.



      A cell-permeable imidazopyridine based compound that lacks canonical zinc chelating moieties and acts in a reversible manner to disrupt heterochromatin-mediated transcriptional gene silencing in mammalian, fungal, and plant cells (5 - 10 µM). Targets Clr3-containing Snf2/HDAC repressor complex (SHREC) and inhibits HDAC6 and HDAC10 activities. Increases G418 resistance of cen1-kanMX cells. Shown to diminish H3K9 methylation and increase H3K9 and H3K14 acetylation in cells grown in the presence of G418. Murine erythroleukemia (MEL) cells grown in the presence of this compound can overcome α-satellite repeats-mediated gene silencing.
      Catalogue Number534034
      Brand Family Calbiochem®
      Synonyms2-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)-6-methylimidazo[1,2-a]pyridine, 2-(2,3-Dihydro-1,4-benzo[b][1,4]dioxin-6-yl)-6-methylimidazo[1,2-a]pyridine, Heterochromatin Mediated Silencing Inhibitor 1
      DescriptionHeterochromatin Inhibitor, HMS-I1
      References
      ReferencesCastonguay, E., et al. 2015. Mol. Cell. Biol. 35, 662.
      Product Information
      FormPale yellow solid
      Hill FormulaC₁₆H₁₄N₂O₂
      Chemical formulaC₁₆H₁₄N₂O₂
      ReversibleY
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetClr3-containing Snf2/HDAC repressor complex (SHREC)
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      534034 0

      Documentation

      Heterochromatin Inhibitor, HMS-I1 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Castonguay, E., et al. 2015. Mol. Cell. Biol. 35, 662.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision25-June-2016 JSW
      Synonyms2-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)-6-methylimidazo[1,2-a]pyridine, 2-(2,3-Dihydro-1,4-benzo[b][1,4]dioxin-6-yl)-6-methylimidazo[1,2-a]pyridine, Heterochromatin Mediated Silencing Inhibitor 1
      DescriptionA cell-permeable imidazopyridine based compound that lacks canonical zinc chelating moieties and acts in a reversible manner to disrupt heterochromatin-mediated transcriptional gene silencing in mammalian, fungal, and plant cells (5 - 10 µM). Targets Clr3-containing Snf2/HDAC repressor complex (SHREC) and inhibits HDAC6 and HDAC10 activities. Increases G418 resistance of cen1-kanMX cells. Shown to diminish H3K9 methylation and increase H3K9 and H3K14 acetylation in cells grown in the presence of G418. Murine erythroleukemia (MEL) cells grown in the presence of this compound can overcome α-satellite repeats-mediated gene silencing.
      FormPale yellow solid
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₁₆H₁₄N₂O₂
      Purity≥98% by HPLC
      SolubilityDMSO (50 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesCastonguay, E., et al. 2015. Mol. Cell. Biol. 35, 662.