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AG252 GAD, control peptide for AB1511

GAD, control peptide for AB1511 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Neurotransmitters & Receptors, Neuronal & Glial Markers Gene Symbol: GAD2, MGC161607, GAD65, MGC161605, GAD-65, EC 4.1.1.15 UniProt Number: Q05329
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AG252
50 µg  
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      Overview

      Replacement Information

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      Description
      Catalogue NumberAG252
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionGAD, control peptide for AB1511
      OverviewSynthetic peptide corresponding to amino acid residues Cys+ 572-585 of rat GAD65 (Erlander et al., 1991). The amino acid sequence is wholly conserved in rat GAD67, and the peptide is located at the C-terminus in both forms of the enzyme. Sequence: [C]DFLIEEIERLGQDL.
      Alternate Names
      • GAD
      References
      Product Information
      PresentationWhite lyophilized powder. Soluble in water.
      Quality LevelMQ100
      Applications
      Key Applications
      • Cell Function Assay
      Application NotesAntibody blocking (AB1511)

      Optimal working dilution must be determined by the end user.
      Biological Information
      Purity>80%
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome.
      Gene Symbol
      • GAD2
      • MGC161607
      • GAD65
      • MGC161605
      • GAD-65
      • EC 4.1.1.15
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q05329 # Catalyzes the production of GABA.
      COFACTOR: Pyridoxal phosphate.
      SIZE: 585 amino acids; 65411 Da
      SUBUNIT: Homodimer (By similarity).
      SUBCELLULAR LOCATION: Cytoplasm, cytosol. Cytoplasmic vesicle. Cell junction, synapse, presynaptic cell membrane; Lipid-anchor. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Note=Associated to cytoplasmic vesicles. In neurons, cytosolic leaflet of Golgi membranes and presynaptic clusters.
      PTM: Phosphorylated; which does not affect kinetic parameters or subcellular location. & Palmitoylated; which is required for presynaptic clustering.
      SIMILARITY: SwissProt: Q05329 ## Belongs to the group II decarboxylase family.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsLong term storage at -20°C in a sealed container with desiccant for up to 12 months after date of receipt.
      Packaging Information
      Material Size50 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      AG252 04053252516412

      Documentation

      GAD, control peptide for AB1511 SDS

      Title

      Safety Data Sheet (SDS) 

      GAD, control peptide for AB1511 Certificates of Analysis

      TitleLot Number
      RAT GLUTAMIC ACID DECARBOXYLASE (GAD65/67) 2479816
      RAT GLUTAMIC ACID DECARBOXYLASE (GAD65/67) CONTROL PEPTIDE - 2159640 2159640
      RAT GLUTAMIC ACID DECARBOXYLASE (GAD65/67) CONTROL PEPTIDE - 2394026 2394026
      RAT GLUTAMIC ACID DECARBOXYLASE (GAD65/67) CONTROL PEPTIDE - 2426536 2426536
      RAT GLUTAMIC ACID DECARBOXYLASE (GAD65/67) - 3810225 3810225
      RAT GLUTAMIC ACID DECARBOXYLASE (GAD65/67) - 3932196 3932196
      RAT GLUTAMIC ACID DECARBOXYLASE (GAD65/67) -2545386 2545386
      RAT GLUTAMIC ACID DECARBOXYLASE (GAD65/67) -2551815 2551815
      RAT GLUTAMIC ACID DECARBOXYLASE (GAD65/67) CONTROL PEPTIDE - 2023678 2023678
      RAT GLUTAMIC ACID DECARBOXYLASE (GAD65/67) CONTROL PEPTIDE - 2058356 2058356

      References

      Reference overviewPub Med ID
      Two genes encode distinct glutamate decarboxylases.
      Erlander, M G, et al.
      Neuron, 7: 91-100 (1991)  1991

      Show Abstract       		2069816 2069816