533259 Sigma-AldrichFOXM1 Inhibitor III, FDI-6 - CAS 313380-27-7 - Calbiochem
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Overview
Key Spec Table
| CAS # | Empirical Formula |
|---|---|
| 313380-27-7 | C₁₉H₁₁F₄N₃OS₂ |
Pricing & Availability
| Catalogue Number | Availability | Packaging | Qty/Pack | Price | Quantity | |
|---|---|---|---|---|---|---|
| 5.33259.0001 |
|
Glass bottle | 10 mg |
|
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| Description | |
|---|---|
| Overview | A cell-permeable thienopyridinylcarboxamide compound that selectively and directly binds to forkhead box M1 (FOXM1) in a 1:1 stoichiometry and reversibly blocks its DNA binding activity (IC50 = 22.5 µM). Does not affect the transcriptional activity of FOXA1, FOXA2, FOXP2, and GATA1 in any significant manner. Shown to suppress the expression of FOXM1 target genes and block the proliferation of FOXM1 expressing breast cancer cells (GI50 = 18 µM for MCF-7 and MDA-MB-231 cells and 21.8 µM for PEO-1 cells). Unlike thiostrepton (Cat. No. 598226), it displays minimal off-target effects and does not affect 20S proteasomal activity. |
| Catalogue Number | 533259 |
| Brand Family | Calbiochem® |
| Synonyms | FDI6, Forkhead Domain Inhibitory Compound 6, NCGC00099374 |
| References | |
|---|---|
| References | Gormally , M.V., et al. 2014. Nat. Commun. 5, 5156. |
| Product Information | |
|---|---|
| CAS number | 313380-27-7 |
| Form | Yellow solid |
| Hill Formula | C₁₉H₁₁F₄N₃OS₂ |
| Chemical formula | C₁₉H₁₁F₄N₃OS₂ |
| Reversible | Y |
| Quality Level | MQ100 |
| Biological Information | |
|---|---|
| Primary Target | FOXM1 |
| Purity | ≥98% by HPLC |
| Physicochemical Information | |
|---|---|
| Cell permeable | Y |
| Packaging Information | |
|---|---|
| Packaged under inert gas | Packaged under inert gas |
| Global Trade Item Number | |
|---|---|
| Catalogue Number | GTIN |
| 5.33259.0001 | 04055977281514 |