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341609 FGF Receptor Tyrosine Kinase Inhibitor IV, NP603 - CAS 949164-80-1 - Calbiochem

The FGF Receptor Tyrosine Kinase Inhibitor IV, NP603 controls the biological activity of FGF Receptor Tyrosine KInase. Primarily used for Phosphorylation & Dephosphorylation applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: (Z)-3-(5-(6-(3,5-Dimethoxyphenyl)-2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-2,4-dimethyl-1H-pyrrol-3-yl)-propionic acid, NP603, VEGFR Tyrosine Kinase Inhibitor XXIX, VEGFR2 Kinase Inhibitor XXVII, PDGFR Tyrosine Kinase Inhibitor XVI

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      Overview

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      949164-80-1C₂₆H₂₆N₂O₅
      Description
      OverviewA cell-permeable SU6668 (PDGFR Tyrosine Kinase Inhibitor VI, Cat. No. 521235) derivative that targets the ATP-binding pocket and inhibits the kinase activity of FGFR1, PDGFRβ, and VEGFR2 (IC50 = 520, 780, and 930 nM, respectively), while exhibiting little activity against EGFR (IC50 >100 µM). Shown to exhibit anti-angiogenesis activity and suppress FGF-2-induced proliferation (IC50 = 18.2 µM) in HUVEC cultures in a dose-dependent manner.
      Catalogue Number341609
      Brand Family Calbiochem®
      Synonyms(Z)-3-(5-(6-(3,5-Dimethoxyphenyl)-2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-2,4-dimethyl-1H-pyrrol-3-yl)-propionic acid, NP603, VEGFR Tyrosine Kinase Inhibitor XXIX, VEGFR2 Kinase Inhibitor XXVII, PDGFR Tyrosine Kinase Inhibitor XVI
      References
      ReferencesKammasud, N., et al. 2009. Bioorg. Med. Chem. Lett. 19, 745.
      Kammasud, N., et al. 2007. Bioorg. Med. Chem. Lett. 17, 4812.
      Product Information
      CAS number949164-80-1
      FormOrange solid
      Hill FormulaC₂₆H₂₆N₂O₅
      Chemical formulaC₂₆H₂₆N₂O₅
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥97% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 22-36/37/38

      Harmful if swallowed.
      Irritating to eyes, respiratory system and skin.
      S PhraseS: 26-36-45

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      341609 0

      Documentation

      FGF Receptor Tyrosine Kinase Inhibitor IV, NP603 - CAS 949164-80-1 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      FGF Receptor Tyrosine Kinase Inhibitor IV, NP603 - CAS 949164-80-1 - Calbiochem Certificates of Analysis

      TitleLot Number
      341609

      References

      Reference overview
      Kammasud, N., et al. 2009. Bioorg. Med. Chem. Lett. 19, 745.
      Kammasud, N., et al. 2007. Bioorg. Med. Chem. Lett. 17, 4812.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision19-May-2011 RFH
      Synonyms(Z)-3-(5-(6-(3,5-Dimethoxyphenyl)-2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-2,4-dimethyl-1H-pyrrol-3-yl)-propionic acid, NP603, VEGFR Tyrosine Kinase Inhibitor XXIX, VEGFR2 Kinase Inhibitor XXVII, PDGFR Tyrosine Kinase Inhibitor XVI
      DescriptionA cell-permeable SU6668 (PDGFR Tyrosine Kinase Inhibitor VI, Cat. No. 521235) derivative that targets the ATP-binding pocket and inhibits the kinase activity of FGFR1, PDGFRβ, and VEGFR2 (IC50 = 520, 780, and 930 nM, respectively), while exhibiting little activity against EGFR (IC50 >100 µM). Shown to exhibit anti-angiogenesis activity and suppress FGF-2-induced proliferation (IC50 = 18.2 µM) in HUVEC cultures in a dose-dependent manner.
      FormOrange solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number949164-80-1
      Chemical formulaC₂₆H₂₆N₂O₅
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityDMSO (100 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Harmful
      ReferencesKammasud, N., et al. 2009. Bioorg. Med. Chem. Lett. 19, 745.
      Kammasud, N., et al. 2007. Bioorg. Med. Chem. Lett. 17, 4812.