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250401 Cytoplasmic Dynein Inhibitor, Ciliobrevin D - CAS 1370554-01-0 - Calbiochem

Overview

Key Spec Table

CAS #Empirical Formula
1370554-01-0C₁₇H₈Cl₃N₃O₂

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250401-10MG
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      Description
      OverviewA cell-permeable benzoyl dihydroquinazolinone derivative that acts as a reversible and specific blocker of AAA+ ATPase motor cytoplasmic dynein and disrupts spindle pole focusing, cold-stable microtubule formation, kinetochore-microtubule attachment, and melanosome aggregation in a dose-dependent manner (~10 to 40 µM). Shown to perturb protein trafficking within the primary cilia and cause a significant increase in intraflagellar transport protein 88 (IFT88) levels at the distal tip of primary cilia. Reported to disrupt primary cilium-dependent Gli regulation and block Hedgehog signaling.
      Catalogue Number250401
      Brand Family Calbiochem®
      Synonyms2-(7-chloro-4-oxo-3,4-dihydroquinazolin-2(1H)-ylidene)-3-(2,4-dichlorophenyl)-3-oxopropanenitrile, AAA+ ATPase motor cytoplasmic dynein inhibitor
      References
      ReferencesFirestone, A., et al. 2012. Nature.
      484, 125.
      Product Information
      CAS number1370554-01-0
      FormOrange powder
      Hill FormulaC₁₇H₈Cl₃N₃O₂
      Chemical formulaC₁₇H₈Cl₃N₃O₂
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Purity≥99% by HPLC
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      250401-10MG 04055977199161