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233183 Clodronate, Disodium Salt - CAS 88416-50-6 - Calbiochem

Overview

Key Spec Table

CAS #Empirical Formula
88416-50-6CH₂Cl₂O₆P₂Na₂ • 4H₂O

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233183-10MG
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      Description
      OverviewA non-amino, chloro-containing bisphosphonate that acts as a potent inhibitor of osteoclast-mediated bone resorption. It is metabolized into a non-hydrolyzable ATP analog in osteoclasts and macrophages, and induces apoptosis by inhibiting mitochondrial function. An efficient metal chelator that inhibits invasion, adhesion, and migration of PC-3 prostate cancer cells (IC50 = 100 nM).
      Catalogue Number233183
      Brand Family Calbiochem®
      SynonymsClodronate, Disodium, Tetrahydrate, Dichloromethylene-bisphosphonate, Disodium Tetrahydrate
      References
      ReferencesLehenkari, P.P., et al. 2002. Mol. Pharmacol. 61, 1255.
      Virtanen, S.S., et al. 2002. Cancer Res. 62, 2708.
      Smith, R., et al. 1971. Lancet 1, 945.
      Fleisch, H., et al. 1969. Nature 223, 211.
      Product Information
      CAS number88416-50-6
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaCH₂Cl₂O₆P₂Na₂ • 4H₂O
      Chemical formulaCH₂Cl₂O₆P₂Na₂ • 4H₂O
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Primary TargetOsteoclast-mediated bone resorption
      Primary Target IC<sub>50</sub>100 nM inhibiting invasion, adhesion, and migration of PC-3 prostate cancer cells
      Purity≥97% by titration
      Physicochemical Information
      Cell permeableN
      Safety Information according to GHS
      RTECSSZ7640700
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Global Trade Item Number
      Catalogue Number GTIN
      233183-10MG 04055977217773