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400015 Caspase-1 Inhibitor IV - CAS 154674-81-4 - Calbiochem

Overview

Key Spec Table

CAS #Empirical Formula
154674-81-4C₃₃H₄₂N₄O₁₀

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400015-1MG
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      Description
      OverviewA highly selective, competitive, cell-permeable, and irreversible inhibitor of caspase-1, caspase-4, and caspase-5. Inactivates the enzyme with a rate limited by diffusion and is relatively inert toward other bionucleophiles such as glutathione, making it an excellent candidate for in vivo studies of enzyme inhibition.
      Catalogue Number400015
      Brand Family Calbiochem®
      SynonymsICE Inhibitor IV, Ac-YVAD-AOM
      References
      ReferencesGarcia-Calvo, M., et al. 1998. J. Biol. Chem. 273, 32608.
      Hilbi, H., et al. 1998. J. Biol. Chem. 273, 32895.
      Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
      Thornberry, N.A., et al. 1994. Biochemistry 33, 3934.
      Product Information
      CAS number154674-81-4
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₃₃H₄₂N₄O₁₀
      Chemical formulaC₃₃H₄₂N₄O₁₀
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Primary Targetcaspase-1
      Purity≥96% by HPLC
      Physicochemical Information
      Cell permeableY
      Peptide SequenceAc-Tyr-Val-Ala-Asp-AOM (AOM = 2,6-dimethylbenzoyloxymethyl ketone)
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Moisture Protect from moisture
      Do not freeze Ok to freeze
      Special InstructionsFollowing recosntitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Global Trade Item Number
      Catalogue Number GTIN
      400015-1MG 07790788049935