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203987 Butein - CAS 487-52-5 - Calbiochem

A cell-permeable, reversible, substrate competitive, plant polyphenol that acts as a specific protein tyrosine kinase inhibitor.

Butein - CAS 487-52-5 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 2ʹ,4ʹ,3,4-Tetrahydroxychalcone

Primary Target: Tyrosine kinase activity of the EGF receptor
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      Overview

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      487-52-5C₁₅H₁₂O₅
      Description
      OverviewA cell-permeable, reversible, substrate competitive, plant polyphenol that acts as a specific protein tyrosine kinase inhibitor. Potently inhibits the tyrosine kinase activity of the EGF receptor (IC50 = 65 µM) and p60c-src (IC50 = 65 µM). The inhibition is competitive with respect to ATP and non-competitive with respect to the substrate. Butein is also a potent antioxidant and anti-inflammatory agent. Has been shown to inhibit glutathione reductase and rat liver glutathione-S-transferase (IC50 = 9 µM). Reported to activate sirtuins and promote the survival of eukaryotic cells.
      Catalogue Number203987
      Brand Family Calbiochem®
      Synonyms2ʹ,4ʹ,3,4-Tetrahydroxychalcone
      References
      ReferencesHowitz, K.T., et al. 2003. Nature 425, 191.
      Chan, S.C., et al. 1998. Planta Med. 64, 153.
      Yang, E.B., et al. 1998. Biochem. Biophys. Res. Commun. 245, 435.
      Zhang, K., et al. 1997. Biochem. Pharmacol. 54, 1047.
      Zhang, K., and Das, N.P. 1994. Biochem. Pharmacol. 47, 2063.
      Product Information
      CAS number487-52-5
      ATP CompetitiveY
      FormYellow solid
      Hill FormulaC₁₅H₁₂O₅
      Chemical formulaC₁₅H₁₂O₅
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetTyrosine kinase activity of the EGF receptor
      Primary Target IC<sub>50</sub>65 µM against tyrosine kinase activity of the EGF receptor
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 weeks at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      203987 0

      Documentation

      Butein - CAS 487-52-5 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Butein - CAS 487-52-5 - Calbiochem Certificates of Analysis

      TitleLot Number
      203987

      References

      Reference overview
      Howitz, K.T., et al. 2003. Nature 425, 191.
      Chan, S.C., et al. 1998. Planta Med. 64, 153.
      Yang, E.B., et al. 1998. Biochem. Biophys. Res. Commun. 245, 435.
      Zhang, K., et al. 1997. Biochem. Pharmacol. 54, 1047.
      Zhang, K., and Das, N.P. 1994. Biochem. Pharmacol. 47, 2063.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision12-January-2010 RFH
      Synonyms2ʹ,4ʹ,3,4-Tetrahydroxychalcone
      DescriptionA cell-permeable, reversible, substrate competitive, plant polyphenol that acts as a specific protein tyrosine kinase inhibitor. Potently inhibits the tyrosine kinase activity of the EGF receptor (IC50 = 65 µM) and p60c-src (IC50 = 65 µM) The inhibition is competitive with respect to ATP and non-competitive with respect to the substrate. Butein is also a potent antioxidant and anti-inflammatory agent. Has been shown to inhibit glutathione reductase (GSH-RD) and rat liver glutathione S-transferase (GST; IC50 = 9 µM). Reported to activate sirtuins and promote the survival of eukaryotic cells.
      FormYellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number487-52-5
      Chemical formulaC₁₅H₁₂O₅
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (10 mg/ml) or Methanol
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 weeks at -20°C.
      Toxicity Standard Handling
      ReferencesHowitz, K.T., et al. 2003. Nature 425, 191.
      Chan, S.C., et al. 1998. Planta Med. 64, 153.
      Yang, E.B., et al. 1998. Biochem. Biophys. Res. Commun. 245, 435.
      Zhang, K., et al. 1997. Biochem. Pharmacol. 54, 1047.
      Zhang, K., and Das, N.P. 1994. Biochem. Pharmacol. 47, 2063.