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178496 Apoptosis Activator VI, CD437/AHPN - CAS 125316-60-1 - Calbiochem

The Apoptosis Activator VI, CD437/AHPN, also referenced under CAS 125316-60-1, modulates Apoptosis. This small molecule/inhibitor is primarily used for Cancer applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 6-(3-(1-Adamantyl)-4-hydroxyphenyl)-2-naphthalene carboxylic acid

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178496
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
125316-60-1C₂₇H₂₆O₃

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178496-5MG
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      Description
      OverviewA cell-permeable retinoid-related molecule that induces tumor growth arrest and apoptosis. The exact molecular basis of the underlying mechanism(s) is not yet well understood, however, studies using ovarian adenocarcinoma cells have shown that CD437/AHPN effectively functions as an ER stress inducer.
      Catalogue Number178496
      Brand Family Calbiochem®
      Synonyms6-(3-(1-Adamantyl)-4-hydroxyphenyl)-2-naphthalene carboxylic acid
      References
      ReferencesWatanabe, Y., et al. 2008. Biochem. Biophys. Res. Comm. 366, 840.
      Holmes, W.F., et al. 2004. J. Cell. Physiol. 199, 317.
      Zhao, X., and Spanjaard, R.A. 2003. J. Biomed. Sci. 10, 44.
      Product Information
      CAS number125316-60-1
      FormOff-white solid
      Hill FormulaC₂₇H₂₆O₃
      Chemical formulaC₂₇H₂₆O₃
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 62-63

      Possible risk of impaired fertility.
      Possible risk of harm to the unborn child.
      S PhraseS: 22-24/25-36/37/39

      Do not breathe dust.
      Avoid contact with skin and eyes.
      Wear suitable protective clothing, gloves and eye/face protection.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Carcinogenic / Teratogenic
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      178496-5MG 04055977204810

      Documentation

      Apoptosis Activator VI, CD437/AHPN - CAS 125316-60-1 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Apoptosis Activator VI, CD437/AHPN - CAS 125316-60-1 - Calbiochem Certificates of Analysis

      TitleLot Number
      178496

      References

      Reference overview
      Watanabe, Y., et al. 2008. Biochem. Biophys. Res. Comm. 366, 840.
      Holmes, W.F., et al. 2004. J. Cell. Physiol. 199, 317.
      Zhao, X., and Spanjaard, R.A. 2003. J. Biomed. Sci. 10, 44.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision29-February-2008 JSW
      Synonyms6-(3-(1-Adamantyl)-4-hydroxyphenyl)-2-naphthalene carboxylic acid
      DescriptionA cell-permeable retinoid-related molecule that induces tumor growth arrest and apoptosis. The exact molecular basis of the underlying mechanism(s) is not yet well understood, however, studies using ovarian adenocarcinoma cells have shown that CD437/AHPN effectively functions as an ER stress inducer.
      FormOff-white solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number125316-60-1
      Chemical formulaC₂₇H₂₆O₃
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (39 mg/ml) or Ethanol (39 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 months at -20°C.
      Toxicity Carcinogenic / Teratogenic
      ReferencesWatanabe, Y., et al. 2008. Biochem. Biophys. Res. Comm. 366, 840.
      Holmes, W.F., et al. 2004. J. Cell. Physiol. 199, 317.
      Zhao, X., and Spanjaard, R.A. 2003. J. Biomed. Sci. 10, 44.