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178385 Apocynin - CAS 498-02-2 - Calbiochem

Overview

Key Spec Table

CAS #Empirical Formula
498-02-2C₉H₁₀O₃

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178385-1GM
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      Description
      OverviewA cell-permeable, anti-inflammatory phenolic compound that acts as a potent and selective inhibitor of NADPH oxidase. Shown to block peroxynitrite formation in murine macrophages. Reported to increase glutathione synthesis through activation of AP-1. Also reported to prevent phagocytosis of myelin by macrophages (10 mM).
      Catalogue Number178385
      Brand Family Calbiochem®
      Synonyms4-Hydroxy-3-methoxyacetophenone, Acetovanillone, NADPH Oxidase Inhibitor V, NOX Inhibitor V
      References
      ReferencesAbid, M.R., et al. 2000. FEBS Lett. 486, 252.
      Muijsers, R.B., et al. 2000. Br. J. Pharmacol. 130, 932.
      Lapperre, T.S., et al. 1999. FEBS Lett. 443, 235.
      Supinski, G., et al. 1999, J. Appl. Physiol. 87, 776.
      van der Goes, A., et al. 1998. J. Neuroimmunol. 92, 67.
      Hart, B.A., and Simmons, J.M. 1992. Biotechnol. Ther. 3, 3.
      Product Information
      CAS number498-02-2
      ATP CompetitiveN
      FormWhite to off-white powder
      Hill FormulaC₉H₁₀O₃
      Chemical formulaC₉H₁₀O₃
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Primary TargetNADPH oxidase
      Purity≥98% by GC
      Physicochemical Information
      Cell permeableY
      Safety Information according to GHS
      RTECSAM8800000
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Irritant
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      178385-1GM 04055977222463