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MABS2279-100UG Anti-Serpin B13 Antibody, clone B34

Anti-Serpin B13, clone B34, Cat. No. MABS2279, is a mouse monoclonal antibody that detects Serpin B13 and is tested for use in Immunohistochemistry (Paraffin).

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MABS2279-100UG
100 μg  
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      Overview

      Replacement Information
      Description
      Catalogue NumberMABS2279-100UG
      DescriptionAnti-Serpin B13 Antibody, clone B34
      Alternate Names
      • Serpin family B member 13
      Background InformationSerpin B13 (UniProt: Q8CDC0; also known as Serpin family B member 13 ) is encoded by the Serpinb13 gene (Gene ID: 241196) in murine species. Serpin B13 is a cytoplasmic protein that plays a role in the proliferation or differentiation of keratinocytes. Two isoforms of Serpin B13 have been described that are generated by alternative splicing. Serpin B13 acts as a serine proteinase inhibitor and studies have shown a strong induction of serpin B13 in the pancreas of mice during the first few weeks of life. Cathepsin L and K appear to be the targets of serpin B13 action. Serpin B13 is expressed in pancreas with low levels of expression in pancreatic islets and larger expression in the exocrine pancreas. Secretion of anti-serpin B13 autoantibodies in young diabetes-prone non-obese diabetic (NOD) mice is shown to be associated with reduced inflammation in pancreatic islets and a slower progression to autoimmune diabetes. Anti-serpin B13 autoantibodies are shown to protect NOD mice against diabetes before 16 weeks of age. Reduced expression of serpin B13 autoantibodies is associated with development of type I diabetes in human before 5 years of age. Mice injected with monoclonal anti-serpin B13 display few inflammatory cells in the islets and rapid recovery from recent onset diabetes. (Ref.: Kryvalap, Y., et al. (2021). Sci. Transl. Med. 13(588); eabf1587; Czyzyk, J. et al. (2012). J. Immunol. 188(12); 6319-6327).
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal antibody IgG2a in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ200
      Applications
      ApplicationAnti-Serpin B13, clone B34, Cat. No. MABS2279, is a mouse monoclonal antibody that detects Serpin B13 and is tested for use in Immunohistochemistry (Paraffin).
      Key Applications
      • Immunohistochemistry (Paraffin)
      Application NotesTested Applications

      Immunohistochemistry Applications: A representative lot detected Serpin B13 in Immunohistochemistry applications (Kryvalap, Y., et al. (2021). Sci Transl Med.13(588):eabf1587).

      Note: Actual optimal working dilutions must be determined by end user as specimens, and experimental conditions may vary with the end user
      Biological Information
      ImmunogenRecombinant full-length mouse Serpin B13.
      EpitopeN-terminal half
      CloneB34
      Concentration1.0 mg/mL. Please refer to guidance on suggested starting dilutions and/or titers per application and sample type.
      HostMouse
      SpecificityClone B34 is a mouse monoclonal antibody that detects mouse Serpin B13.
      IsotypeIgG2aκ
      Species Reactivity
      • Mouse
      Species Reactivity NoteMouse.
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • Serpinb13
      Purification MethodProtein G purified
      UniProt Number
      Molecular Weight44.32 kDa calculated.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Immunohistochemistry (Paraffin) in mouse skin tissue sections.

      Immunohistochemistry (Paraffin) Analysis: A 1:50 dilution of this antibody detected Serpin B13 in mouse skin tissue sections.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsRecommended storage: +2°C to +8°C.
      Packaging Information
      Material Size100 μg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      MABS2279-100UG 04065267061672