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MABC532 Anti-PTHrP Antibody, clone 4C4.1

Detect PTHLH using this mouse monoclonal Anti-PTHrP Antibody, clone 4C4.1, Cat. No. MABC532, validated for use in Western Blotting.

Anti-PTHrP Antibody, clone 4C4.1 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Apoptosis & Cancer Research Sub-Category: Apoptosis - Additional Gene Symbol: PTHRP, PTHLH UniProt Number: P12272
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MABC532
100 μg  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWBMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABC532
      DescriptionAnti-PTHrP Antibody, clone 4C4.1
      Alternate Names
      • Parathyroid hormone-related protein
      • PTHrP
      • PTH-rP
      • Parathyroid hormone-like protein
      • PLP
      Background InformationParathyroid hormone-related protein (UniProt P12272; also known as Parathyroid hormone-like related protein, Parathyroid hormone-like hormone preproprotein, PLP, PTH-related protein, PTH-rP, PTHrP) is encoded by the PTHLH (also known as BDE2, HHM, PTHR, PTHRP) gene (Entrez Gene ID 5744) in human. Parathyroid hormone-related protein is initially translated as a 177 amino acid preproprotein with an N-terminal signal sequence (aa 1-24) and a propeptide sequence (aa 25-34), which are later removed to yield the mature protein. The mature protein is further cleaved to produce PTHrP[1-34] (aa 37-70), PTHrP[1-36] (aa 37-72), PTHrP[38-94] (aa 74-130), and PTHrP[107-139] (aa 143-175; also known as Osteostatin). PTHrP is produced in a wide variety of tissues, where it acts as a paracrine or autocrine factor to regulate cellular and organ growth, development, migration, differentiation, calcium transport, survival and apoptosis.
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal IgG1κ antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationDetect PTHLH using this mouse monoclonal Anti-PTHrP Antibody, clone 4C4.1, Cat. No. MABC532, validated for use in Western Blotting.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenGST-tagged recombinant human PTHrP lacking signal and propeptide sequence.
      Clone4C4.1
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      IsotypeIgG1κ
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • PTHRP
      • PTHLH
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight~16/6 kDa observed. Uncharacterized band(s) may appear in some lysates.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in MCF-7 cell lysate.

      Western Blotting Analysis: 2.0 µg/mL of this antibody detected PTHrP in 10 µg of MCF-7 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 μg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      MABC532 04055977177039

      Documentation

      Anti-PTHrP Antibody, clone 4C4.1 SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-PTHrP Antibody, clone 4C4.1 Certificates of Analysis

      TitleLot Number
      Anti-PTHrP, clone 4C4.1 - 3590793 3590793
      Anti-PTHrP, clone 4C4.1 - 3900419 3900419
      Anti-PTHrP, clone 4C4.1 - 4080140 4080140
      Anti-PTHrP, clone 4C4.1 -Q2583333 Q2583333
      Anti-PTHrP, clone 4C4.1 Monoclonal Antibody 3792040

      Technical Info

      Title
      Characterization of Estrogen Receptor α Phosphorylation Sites in Breast Cancer Tissue Using the SNAP i.d® 2.0 System
      White Paper: Further considerations of antibody validation and usage.

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies