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AB1526P Anti-Nerve Growth Factor-β Antibody, pain

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AB1526P
20 µg  
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      Overview

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      Ch, H, M, RELISA, WB, IHC, FUNCRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberAB1526P
      Replaces04-1119
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Nerve Growth Factor-β Antibody, pain
      Alternate Names
      • NGFbeta
      Product Information
      FormatAffinity Purified
      PresentationAffinity purified immunoglobulin. Lyophilized from PBS. Contains no preservative. Reconstitute to desired volume with sterile distilled water. Suggested concentration 0.5-1.0 mg/mL.
      Quality LevelMQ100
      Applications
      ApplicationThis Anti-Nerve Growth Factor-β Antibody, pain is validated for use in ELISA, WB, IH, FUNC for the detection of Nerve Growth Factor-β.
      Key Applications
      • ELISA
      • Western Blotting
      • Immunohistochemistry
      • Affects Function
      Application NotesImmunohistochemistry: 1-2 μg/mL (see suggested protocol).

      Immunoblotting: 1-2 μg/mL

      Bioassays (Inhibition of biological activity in vitro): 1-2 μg/mL

      in vivo animal studies: use neat

      ELISA: 1-2 μg/mL

      Optimal working dilutions must be determined by the end user.

      BIOLOGICAL ACTIVITY:

      This antibody completely inhibits neuron survival and the outgrowth actions of mouse NGF in chicken dorsal root ganglion in vitro.
      Biological Information
      ImmunogenMouse nerve growth factor-beta purified from salivary glands.
      HostRabbit
      SpecificityNerve growth factor-beta (NGF). Less than 1% cross-reactivity against recombinant human BDNF, NT3 and NT4 by ELISA.
      Species Reactivity
      • Chicken
      • Human
      • Mouse
      • Rat
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene is a member of the NGF-beta family and encodes a secreted protein which homodimerizes and is incorporated into a larger complex. This protein has nerve growth stimulating activity and the complex is involved in the regulation of growth and the differentiation of sympathetic and certain sensory neurons. Mutations in this gene have been associated with hereditary sensory and autonomic neuropathy, type 5 (HSAN5), and dysregulation of this gene's expression is associated with allergic rhinitis.
      Gene Symbol
      • NGFB
      • MGC161426
      • HSAN5
      • NGF
      • Beta-NGF
      • MGC161428
      Non-Reactive Species
      • Bovine
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P01138 # Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. It stimulates division and differentiation of sympathetic and embryonic sensory neurons.
      SIZE: 241 amino acids; 26959 Da
      SUBUNIT: Homodimer.
      SUBCELLULAR LOCATION: Secreted.
      DISEASE: SwissProt: P01138 # Defects in NGFB are the cause of hereditary sensory and autonomic neuropathy type 5 (HSAN5) [MIM:608654]. Hereditary sensory and autonomic neuropathies are characterized by loss of pain sensation in combination with other sensory and/or autonomic abnormalities. HSAN5 patients manifest loss of pain perception and impaired temperature sensitivity, ulcers, and in some cases self- mutilation. The autonomic involvement is variable.
      SIMILARITY: SwissProt: P01138 ## Belongs to the NGF-beta family.
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at lyophilized material at -20 to -70°C for up to 12 months after date of receipt. After reconstitution maintain at -20 to -70°C in undiluted aliquots for up to six months. Avoid repeated freeze/thaw cycles.
      Packaging Information
      Material Size20 µg
      Global Trade Item Number
      Catalogue Number GTIN
      AB1526P 04053252468841