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ABN307 Anti-LGI1 Antibody

Detect the LGI1 protein using this Anti-LGI1 validated for use in WB & IHC.

Anti-LGI1 Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Developmental Neuroscience Gene Symbol: LGI1 UniProt Number: O95970
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ABN307
100 µg  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      M, R, HWB, IHCRbPurifiedPolyclonal Antibody
      Description
      Catalogue NumberABN307
      DescriptionAnti-LGI1 Antibody
      Alternate Names
      • Leucine-rich
      • glioma inactivated 1
      • epitempin
      • EPT
      Background InformationThe leucine-rich, glioma inactivated gene 1 (LGI1) was first identified as tumor suppressor gene for glioma and may play a role in other cancers. LGI1 is a member of a family of highly related proteins containing leucine-rich repeats (LRRs) which are very similar to other transmembrane signaling molecules and receptors. LGI1 serves as a ligand to ADAM22, a metalloprotease localized at the synapse. Mutations in LGI1 account for nearly half of autodominant lateral temporal epilepsy (ADTLE), an epileptic syndrome characterized by focal seizures with predominant auditory symptoms.
      References
      Product Information
      FormatPurified
      Control
      • Mouse brain tissue lysate
      PresentationPurified rabbit polyclonal in buffer containing PBS with 0.02% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationDetect the LGI1 protein using this Anti-LGI1 validated for use in WB & IHC.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      Application NotesWestern Blot Analysis: 2 µg/mL from a representative lot detected LGI1 in 10 µg/mL of HEK293 cell lysate.

      Immunohistochemistry Analysis: A 1:2,000 dilution from a representative lot detected LGI1 in mouse cerebellum and rat cortex tissues.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to human LGI1.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityThis antibody recognizes only Isoform 1.
      Species Reactivity
      • Mouse
      • Rat
      • Human
      Antibody TypePolyclonal Antibody
      Gene Symbol
      • LGI1
      Purification MethodAntigen Affinity Purified
      UniProt Number
      Molecular Weight~64 kDa observed. Uniprot describes 3 isoforms at ~33 kDa, ~58 kDa, and ~64 kDa. An uncharacterized band may appear at ~45 kDa in some lysates.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in mouse brain tissue lysate.

      Western Blot Analysis: 2 µg/mL of this antibody detected LGI1 in 10 µg/mL of mouse brain tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      ABN307 04053252831041

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies