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ABC844 Anti-IEX1 Antibody

Anti-IEX1 Antibody is an antibody against IEX1 for use in western blotting, IHC & immunofluorescence.

Anti-IEX1 Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Apoptosis & Cancer Research Sub-Category: Apoptosis - Additional Gene Symbol: IER3, DIF2, IEX1, PRG1 UniProt Number: P46695
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ABC844
100 µg  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWB, IHC, IFRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberABC844
      DescriptionAnti-IEX1 Antibody
      Alternate Names
      • Radiation-inducible immediate-early gene IEX-1
      • Differentiation-dependent gene 2 protein
      • Protein DIF-2
      • Immediate early protein GLY96
      • Immediate early response 3 protein
      • PACAP-responsive gene 1 protein
      • Protein PRG1
      • IEX1
      Background InformationRadiation-inducible immediate-early gene IEX-1, also known as Differentiation-dependent gene 2 protein (DIF-2) or PACAP-responsive gene 1 protein (Protein PRG1), and encoded by the gene name IER3 or DIF2 or IEX1 or PRG1, is a stress inducible gene that is induced by ionizing radiation, ultraviolet radiation, and a variety of growth factors, i.e., FAS and TNF-α. IEX1 is widely expressed in epithelial and endocrine tissues, as well as in vascular endothelium. IEX1 plays an important role in the regulation of cellular growth, cell death and oncogenesis and is precisely regulated by multiple transcription factors such as p53, NF-κB/rel, Sp1 and c-Myc, to ensure rapid and transient expression of IEX1 in cells under a variety of stress conditions. IEX1 is expressed as both a longer form (IEX1L) and a splice variant, designated IEX1S. It is localized to the nucleus and perinuclear region. Overexpression of IEX1 facilitates apoptosis and cell cycle progression, whereas disruption of IEX1 expression is associated with decreases in both apoptosis and cell cycle progression.
      References
      Product Information
      FormatAffinity Purified
      PresentationPurified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-IEX1 Antibody is an antibody against IEX1 for use in western blotting, IHC & immunofluorescence.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      • Immunofluorescence
      Application NotesImmunohistochemistry Analysis: 2.5 μg/mL from a representative lot detected IEX1 in human liver tissue.

      Immunofluorescence Analysis: 20 μg/mL from a representative lot detected IEX1 in human brain cells.
      Biological Information
      ImmunogenKLH-conjugated synthetic peptide corresponding to the center region of human IEX1.
      EpitopeCenter region
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      Species Reactivity
      • Human
      Antibody TypePolyclonal Antibody
      Gene Symbol
      • IER3
      • DIF2
      • IEX1
      • PRG1
      Purification MethodAffinity
      UniProt Number
      Molecular Weight~16 kDa observed. Uncharacterized bands may be observed in some lysate(s).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in human brain tissue lysate.

      Western Blotting Analysis: 4 μg/mL of this antibody detected IEX1 in human brain tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      ABC844 04053252944109