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251010 1-β-D-Arabinofuranosylcytosine - CAS 147-94-4 - Calbiochem

Anticancer, antiviral agent that is especially effective against leukemias.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Ara-C, Cytarabine, Cytosine Arabinoside

Primary Target: Anticancer, antiviral agent that is especially effective against leukemias
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251010
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Overview

Key Spec Table

CAS #Empirical Formula
147-94-4C₉H₁₃N₃O₅

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251010-1GM
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      Description
      OverviewAnticancer, antiviral agent that is especially effective against leukemias. Induces apoptosis in human myeloid leukemia cells and in rat sympathetic neurons. Induces G1/S phase cell cycle arrest.
      Catalogue Number251010
      Brand Family Calbiochem®
      SynonymsAra-C, Cytarabine, Cytosine Arabinoside
      References
      ReferencesZarilli, R., et al. 1999. Gastroenterology 116, 1358.
      Dessi, F., et al. 1995. J. Neurochem. 64, 1980.
      Grant, S., et al. 1994. Oncol. Res. 6, 87.
      Greenberg, A.L., et al. 1994. Cancer 74, 1261.
      Perrino, F.W., et al. 1997. J. Biol. Chem. 269, 16357.
      Tomkins, C.E., et al. 1994. J. Cell Sci. 107, 1499.
      Taddie, J.A., and Traktman, P. 1993. J. Virol. 67, 4323.
      Brach, M.A., et al. 1992. Mol. Pharmacol. 41, 60.
      Este, E., et al. 1992. Blood 79, 2246.
      Owens, J.K., et al. 1992. Cancer Res. 52, 2389.
      Product Information
      CAS number147-94-4
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₉H₁₃N₃O₅
      Chemical formulaC₉H₁₃N₃O₅
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Primary TargetAnticancer, antiviral agent that is especially effective against leukemias
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableN
      Safety Information according to GHS
      RTECSHA5425000
      Safety Information
      R PhraseR: 20/21/22-36/37/38-43-61

      Harmful by inhalation, in contact with skin and if swallowed.
      Irritating to eyes, respiratory system and skin.
      May cause sensitization by skin contact.
      May cause harm to the unborn child.
      S PhraseS: 22-36-45

      Do not breathe dust.
      Wear suitable protective clothing.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful & Carcinogenic / Teratogenic
      Storage +2°C to +8°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 6 months at -70°C.
      Global Trade Item Number
      Catalogue Number GTIN
      251010-1GM 04055977199192