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565767 α-Secretase Substrate II, Fluorogenic - Calbiochem

An internally quenched fluorogenic peptide substrate containing the α-secretase cleavage site of β-Amyloid Precursor Protein (APP).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Ac-RE(EDANS)-VHHQKLVF-K(DABCYL)-R-OH

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565767
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565767-1MG
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      Description
      OverviewAn internally quenched fluorogenic peptide substrate containing the α-secretase cleavage site of β-Amyloid Precursor Protein (APP). Shown to be a substrate for yapsin 2, a glycosyl-phosphatidylinositol-linked yeast aspartyl protease (Vmax/Km = 0.031 min-1). The cleavage is shown to occur at the Lys-Leu bond.
      Catalogue Number565767
      Brand Family Calbiochem®
      SynonymsAc-RE(EDANS)-VHHQKLVF-K(DABCYL)-R-OH
      References
      ReferencesKomano, H., et al. 1999. J. Biol. Chem. 274, 24431.
      Komano, H., et al. 1998. J. Biol. Chem. 273, 31648.
      Product Information
      ATP CompetitiveN
      FormRed solid
      FormulationSupplied as a trifluoroacetate salt.
      Hill FormulaC₁₀₀H₁₄₄N₃₀O₂₀S
      Chemical formulaC₁₀₀H₁₄₄N₃₀O₂₀S
      Hygroscopic Hygroscopic
      ReversibleN
      Quality LevelMQ100
      Biological Information
      Primary TargetSubstrate containing the α-secretase cleavage site of β-Amyloid Precursor Protein (APP)
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableN
      Emission max.
      Excitation max.
      Peptide SequenceAc-Arg-Glu(EDANS)-Val-His-His-Gln-Lys-Leu-Val-Phe-Lys(DABCYL)-Arg-OH
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      565767-1MG 04055977267754