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525145 sPLA₂-IIA Inhibitor I - Calbiochem

The sPLA₂-IIA Inhibitor I controls the biological activity of sPLA₂-IIA. This small molecule/inhibitor is primarily used for Cell Signaling applications.

sPLA₂-IIA Inhibitor I - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: c(2NapA)LS(2NapA)R, TFA

Primary Target: sPLA2-IIA (human type IIA secreted phospholipase A2
525145
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Overview

Key Spec Table

Empirical Formula
C₄₁H₅₀N₈O₆ · CF₃CO₂H

Products

Catalogue NumberPackaging Qty/Pack
525145-1MG Plastic ampoule 1 mg
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Description
OverviewA highly hydrophobic cyclic pentapeptide that selectively binds and acts as a potent inhibitor of sPLA2-IIA (human type IIA secreted phospholipase A2; IC50 = 12.8 μM). Shown to effectively block sPLA2-IIA-induced PGE2 production at 100 nM in human rheumatoid synoviocytes and is non-toxic at doses up to 10 μM. Does not have any significant effect on the activities of porcine sPLA2-IB, Naja naja sPLA2-IB, or Crotalus durissus sPLA2-IIA even at 10 μM concentration.
Catalogue Number525145
Brand Family Calbiochem®
Synonymsc(2NapA)LS(2NapA)R, TFA
References
ReferencesChurch, W.B., et al. 2001. J. Biol. Chem. 276, 33156.
Product Information
ATP CompetitiveN
FormWhite lyophilized solid
FormulationSupplied as a trifluoroacetate salt.
Hill FormulaC₄₁H₅₀N₈O₆ · CF₃CO₂H
Chemical formulaC₄₁H₅₀N₈O₆ · CF₃CO₂H
Hygroscopic Hygroscopic
ReversibleN
Quality LevelMQ100
Biological Information
Primary TargetsPLA2-IIA (human type IIA secreted phospholipase A2
Primary Target IC<sub>50</sub>12.8 µM against sPLA2-IIA (human type IIA secreted phospholipase A2
Purity≥95% by HPLC
Physicochemical Information
Cell permeableN
Peptide Sequencecyclic(2-NaphthylAla-Leu-Ser-2-NaphthylAla-Arg)•TFA
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Catalogue Number GTIN
525145-1MG 04055977197136