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500609 Temozolomide - CAS 85622-93-1 - Calbiochem

Temozolomide - CAS 85622-93-1 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: NSC 362856, 3-Methyl-4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-carboxamide, CCRG 81045, TMZ, 3,4-Dihydro-3-methyl-4-oxoimidazo[5,1-d][1,2,3,5]tetrazine-8-carboxamide

Primary Target: DNA guanine residues
500609
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
85622-93-1C₆H₆N₆O₂

Products

Catalogue NumberPackaging Qty/Pack
5006090001 Glass bottle 50 mg
Description
OverviewA cell-permeable, orally bioavailable, blood-brain barrier-permeant MTIC [5-(3-methyltriazen-1-yl-)-imidazole-4-carboxamide] prodrug whose in vivo DNA alkylating activity is employed in anticancer therapy. MGMT (O6-methylguanine DNA methyl transferase) repairs TMZ-damaged DNA lesion by covalently transferring O6-methylation on guanine residues to a cysteine residue on the MGMT, forming the basis of TMZ-resistance in cancer treatment.

Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.
Catalogue Number500609
Brand Family Calbiochem®
SynonymsNSC 362856, 3-Methyl-4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-carboxamide, CCRG 81045, TMZ, 3,4-Dihydro-3-methyl-4-oxoimidazo[5,1-d][1,2,3,5]tetrazine-8-carboxamide
References
ReferencesNeyns, B., et al. 2010. Cancer 116, 2868.
Marchesi, F., et al. 2007. Pharmacol. Res. 56, 275.
Chakravarti, A., et al. 2006. Clin. Cancer Res. 12, 4738.
Natsume, A., et al. 2005. Cancer Res. 65, 7573.
Jen, J.F., et al. 2000. Pharm. Res. 17, 1284.
Product Information
CAS number85622-93-1
FormOff-white solid
Hill FormulaC₆H₆N₆O₂
Chemical formulaC₆H₆N₆O₂
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetDNA guanine residues
Purity≥99% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 23/24/25-36/37/38-45-46

Toxic by inhalation, in contact with skin and if swallowed.
Irritating to eyes, respiratory system and skin.
May cause cancer.
May cause heritable genetic damage.
S PhraseS: 26-36-45

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Harmful & Carcinogenic / Teratogenic
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
5006090001 04055977244991

Documentation

Temozolomide - CAS 85622-93-1 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

References

Reference overview
Neyns, B., et al. 2010. Cancer 116, 2868.
Marchesi, F., et al. 2007. Pharmacol. Res. 56, 275.
Chakravarti, A., et al. 2006. Clin. Cancer Res. 12, 4738.
Natsume, A., et al. 2005. Cancer Res. 65, 7573.
Jen, J.F., et al. 2000. Pharm. Res. 17, 1284.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision10-May-2013 JSW
SynonymsNSC 362856, 3-Methyl-4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-carboxamide, CCRG 81045, TMZ, 3,4-Dihydro-3-methyl-4-oxoimidazo[5,1-d][1,2,3,5]tetrazine-8-carboxamide
DescriptionA cell-permeable, orally bioavailable, blood-brain barrier-permeant MTIC [5-(3-methyltriazen-1-yl-)-imidazole-4-carboxamide] prodrug whose in vivo DNA alkylating activity is employed in anticancer therapy. MGMT (O6-methylguanine DNA methyl transferase) repairs TMZ-damaged DNA lesion by covalently transferring O6-methylation on guanine residues to a cysteine residue on the MGMT, forming the basis of TMZ-resistance in cancer treatment.
FormOff-white solid
Intert gas (Yes/No) Packaged under inert gas
CAS number85622-93-1
Chemical formulaC₆H₆N₆O₂
Structure formulaStructure formula
Purity≥99% by HPLC
SolubilityDMSO (25 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Harmful & Carcinogenic / Teratogenic
ReferencesNeyns, B., et al. 2010. Cancer 116, 2868.
Marchesi, F., et al. 2007. Pharmacol. Res. 56, 275.
Chakravarti, A., et al. 2006. Clin. Cancer Res. 12, 4738.
Natsume, A., et al. 2005. Cancer Res. 65, 7573.
Jen, J.F., et al. 2000. Pharm. Res. 17, 1284.