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580222 Tau Aggregation Inhibitor, ATPZ, Cpd16 - Calbiochem

580222
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Overview

Products

Catalogue NumberPackaging Qty/Pack
580222-10MG Glass bottle 10 mg
Description
OverviewA water soluble (32uM in water) BBB-permeable ATPZ (aminothienopyridazine) tau aggregation inhibitor that exhibited IC50 of 8.1uM in a heparin-induced tau assembly assay (monitored by thioflavine-T binding and fluorescence), and was further validated in vitro to reduce tau fibril formation (tau fragment K18PL, and full length tau40) by >50% in sedimentation assays. It also displayed very good B/P ratio (1.6) in a mice full PK study with good oral bioavailability and good metabolic stability. No cytotoxicity was observed at up to 100uM in HEK-293 cells.
Catalogue Number580222
Brand Family Calbiochem®
Synonyms5-amino-3-(4-chlorophenyl)-N-cyclopropyl-4-oxo-3,4-dihydrothieno[3,4-d]pyridazine-1-carboxamide
References
ReferencesBallatore, C., et al. 2010. J. Med. Chem. 53, 3739.
Product Information
FormOrange powder
Hill FormulaC₁₆H₁₃ClN₄O₂S
Chemical formulaC₁₆H₁₃ClN₄O₂S
Structure formula ImageStructure formula Image
Quality LevelMQ100
Biological Information
Purity≥95% by HPLC
Storage and Shipping Information
Ship Code Shipped with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage -20°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Global Trade Item Number
Catalogue Number GTIN
580222-10MG 04055977265453