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Buffer Detection Kit for Magnetic Beads
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567750
Sigma-AldrichSplitomicin - CAS 5690-03-9 - Calbiochem
A cell-permeable lactone derived from β-naphthol that acts as a selective inhibitor of NAD+-dependent histone deacetylase activity of Sir2 protein (IC₅₀ = 60 µM).
More>>A cell-permeable lactone derived from β-naphthol that acts as a selective inhibitor of NAD+-dependent histone deacetylase activity of Sir2 protein (IC₅₀ = 60 µM). Less<<
Splitomicin - CAS 5690-03-9 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
A cell-permeable lactone derived from β-naphthol that acts as a selective inhibitor of NAD+-dependent histone deacetylase activity of Sir2 protein (IC50 = 60 µM). It creates a conditional phenocopy of a sir2 deletion mutant in S. cerevisiae and sensitizes mammalian cells to a variety of DNA-damaging agents by abrogating Sir2p activity on p53. Acts by either altering or blocking access to the acetylated histone binding pocket.
Catalogue Number
567750
Brand Family
Calbiochem®
Synonyms
1,2-Dihydro-3H-naphtho[2,1-b]pyran-3-one
References
References
Bedalov, A., et al. 2001. Proc. Natl. Acad. Sci. USA98, 15113.
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
Revision
11-September-2008 RFH
Synonyms
1,2-Dihydro-3H-naphtho[2,1-b]pyran-3-one
Description
A cell-permeable and selective inhibitor of NAD+-dependent deacetylase activity of Sir2 protein (IC50 = 60 µM). Creates a phenocopy of the sir2 deletion mutant in S. cerevisiae and sensitizes mammalian cells to a variety of DNA-damaging agents by abrogating Sir2p activity on p53. Reported to act by either altering or blocking access to the acetylated histone-binding pocket.
Form
Off-white powder
Intert gas (Yes/No)
Packaged under inert gas
CAS number
5690-03-9
Chemical formula
C₁₃H₁₀O₂
Structure formula
Purity
≥95% by HPLC
Solubility
DMSO (100 mg/ml)
Storage
Protect from light +2°C to +8°C
Do Not Freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity
Standard Handling
References
Bedalov, A., et al. 2001. Proc. Natl. Acad. Sci. USA98, 15113.