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567750 Splitomicin - CAS 5690-03-9 - Calbiochem

567750
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Overview

Key Spec Table

CAS #Empirical Formula
5690-03-9C₁₃H₁₀O₂

Products

Catalogue NumberPackaging Qty/Pack
567750-5MG Plastic ampoule 5 mg
Description
OverviewA cell-permeable lactone derived from β-naphthol that acts as a selective inhibitor of NAD+-dependent histone deacetylase activity of Sir2 protein (IC50 = 60 µM). It creates a conditional phenocopy of a sir2 deletion mutant in S. cerevisiae and sensitizes mammalian cells to a variety of DNA-damaging agents by abrogating Sir2p activity on p53. Acts by either altering or blocking access to the acetylated histone binding pocket.
Catalogue Number567750
Brand Family Calbiochem®
Synonyms1,2-Dihydro-3H-naphtho[2,1-b]pyran-3-one
References
ReferencesBedalov, A., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 15113.
Product Information
CAS number5690-03-9
ATP CompetitiveN
FormOff-white powder
Hill FormulaC₁₃H₁₀O₂
Chemical formulaC₁₃H₁₀O₂
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Biological Information
Primary TargetNAD+-dependent histone deacetylase activity of Sir2 protein
Primary Target IC<sub>50</sub>60 µM against NAD+-dependent histone deacetylase activity of Sir2 protein
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Catalogue Number GTIN
567750-5MG 04055977190946