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567417 SOD1 Inhibitor, LCS-1 - CAS 41931-13-9 - Calbiochem

The SOD1 Inhibitor, LCS-1, also referenced under CAS 41931-13-9, controls the biological activity of SOD1.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: lung cancer screen 1, 4,5-dichloro-2-m-tolylpyridazin-3(2H)-one, 4,5-dichloro-2-(3-methylphenyl)-3(2H)-pyridazinone, Superoxide dismutase 1 inhibitor

567417
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
41931-13-9C₁₁H₈Cl₂N₂O

Products

Catalogue NumberPackaging Qty/Pack
567417-10MG Glass bottle 10 mg
Description
OverviewA 2-phenylpyridazin-3(2H)-one based non-copper chelater that selectively inhibits the activity of Superoxide dismutase 1 (Cu/Zn-SOD) (IC50 = 1.07 µM). Cells over-expressing SOD1 show reduced sensitivity to LCS-1. Shown to preferably inhibit the growth of a variety of human lung adenocarinoma cell lines with EGFR and KRAS mutations (IC50 = 200 nM). Prevents serum-induced activation of the ERK and PI 3-kinase/AKT signaling thereby affecting cell growth and survival. Apparent half-life of this compound is reported to be 6.6 min in human liver microsomes.
Catalogue Number567417
Brand Family Calbiochem®
Synonymslung cancer screen 1, 4,5-dichloro-2-m-tolylpyridazin-3(2H)-one, 4,5-dichloro-2-(3-methylphenyl)-3(2H)-pyridazinone, Superoxide dismutase 1 inhibitor
References
ReferencesSomwar, R., et al. 2011, PNAS in press.
Somwar, R., et al. 2009. J. Biomol. Screen 14, 1176
Product Information
CAS number41931-13-9
FormWhite solid
Hill FormulaC₁₁H₈Cl₂N₂O
Chemical formulaC₁₁H₈Cl₂N₂O
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥99% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
567417-10MG 04055977267242

Documentation

SOD1 Inhibitor, LCS-1 - CAS 41931-13-9 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

SOD1 Inhibitor, LCS-1 - CAS 41931-13-9 - Calbiochem Certificates of Analysis

TitleLot Number
567417

References

Reference overview
Somwar, R., et al. 2011, PNAS in press.
Somwar, R., et al. 2009. J. Biomol. Screen 14, 1176
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision27-June-2012 JSW
Synonymslung cancer screen 1, 4,5-dichloro-2-m-tolylpyridazin-3(2H)-one, 4,5-dichloro-2-(3-methylphenyl)-3(2H)-pyridazinone, Superoxide dismutase 1 inhibitor
DescriptionA 2-phenylpyridazin-3(2H)-one based non-copper chelater that selectively inhibits the activity of Superoxide dismutase 1 (Cu/Zn-SOD) (IC50 = 1.07 µM). Cells over-expressing SOD1 show reduced sensitivity to LCS-1. Shown to preferably inhibit the growth of a variety of human lung adenocarinoma cell lines with EGFR and KRAS mutations (IC50 = 200 nM). Prevents serum-induced activation of the ERK and PI 3-kinase/AKT signaling thereby affecting cell growth and survival. Apparent half-life of this compound is reported to be 6.6 min in human liver microsomes.
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
CAS number41931-13-9
Chemical formulaC₁₁H₈Cl₂N₂O
Structure formulaStructure formula
Purity≥99% by HPLC
SolubilityDMSO (50 mg/mlg; clear, colorless solution)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesSomwar, R., et al. 2011, PNAS in press.
Somwar, R., et al. 2009. J. Biomol. Screen 14, 1176