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557370 Rottlerin - CAS 82-08-6 - Calbiochem

Rottlerin, CAS 82-08-6, is a cell-permeable, reversible inhibitor of protein kinase C with greater selectivity for PKCδ (IC50 = 3-6 µM) & PKCθ. Has about 10-fold lower potency against other isozymes.

Rottlerin - CAS 82-08-6 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Mallotoxin

Primary Target: PKCδ
557370
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
82-08-6C₃₀H₂₈O₈

Products

Catalogue NumberPackaging Qty/Pack
557370-10MG Plastic ampoule 10 mg
Description
OverviewA cell-permeable and reversible protein kinase C inhibitor that exhibits greater selectivity for PKCδ (IC50 = 3-6 µM) and PKCθ. Inhibits the PKCα, PKCβ, and PKCγ isoforms, but with significantly reduced potency (IC50 = 30-42 µM). Has reduced inhibitory activity on PKCε, PKCη, and PKCζ (IC50 = 80-100 µM). Also known to inhibit CaM kinase III (IC50 = 5.3 µM).
Catalogue Number557370
Brand Family Calbiochem®
SynonymsMallotoxin
References
ReferencesVillalba, M., et al. 1999. J. Immunol. 163, 5813.
Gschwendt, M., et al. 1994. Biochem. Biophys. Res. Commun. 199, 93.
Gschwendt, M., et al. 1994. FEBS Lett. 338, 85.
Gschwendt, M., et al. 1984. Cancer Lett. 25, 177.
Product Information
CAS number82-08-6
ATP CompetitiveN
FormOrange solid
Hill FormulaC₃₀H₂₈O₈
Chemical formulaC₃₀H₂₈O₈
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationRottlerin, CAS 82-08-6, is a cell-permeable, reversible inhibitor of protein kinase C with greater selectivity for PKCδ (IC50 = 3-6 µM) & PKCθ. Has about 10-fold lower potency against other isozymes.
Biological Information
Primary TargetPKCδ
Primary Target IC<sub>50</sub>3-6 µM against PKCδ; 5.3 µM against CaM kinase III
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSAM6913800
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
557370-10MG 04055977268041

Documentation

Rottlerin - CAS 82-08-6 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Rottlerin - CAS 82-08-6 - Calbiochem Certificates of Analysis

TitleLot Number
557370

References

Reference overview
Villalba, M., et al. 1999. J. Immunol. 163, 5813.
Gschwendt, M., et al. 1994. Biochem. Biophys. Res. Commun. 199, 93.
Gschwendt, M., et al. 1994. FEBS Lett. 338, 85.
Gschwendt, M., et al. 1984. Cancer Lett. 25, 177.

Citations

Title
  • Phuong Thi Nguyen Sarkis, et al. (2006) STAT1-independent cell type-specific regulation of antiviral APOBEC3G by IFN-α. Journal of Immunology 177, 4530-4540.
  • Ying Zhang, Mingjuan Liao and Maria L. Dufau. (2006) Phosphatidylinositol 3-kinase/protein kinase Cγ-induced phosphorylation of Sp1 and p107 repressor release have a critical role in histone deacetylase inhibitor-mediated depression of transcription of the luteinizing hormone receptor gene. Molecular and Cellular Biology 26, 6748-6761.
  • Yoon-Jin Lee, et al. (2005) HSP25 inhibits protein kinase Cγ-mediated cell death through direct interaction. Journal of Biological Chemistry 280, 18108-18119.
    		•
    Data Sheet

    Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

    Revision11-January-2010 RFH
    SynonymsMallotoxin
    DescriptionA cell-permeable and reversible inhibitor of protein kinase C δ (PKCδ, IC50 = 3-6 µM) and PKCΘ isozymes. Also inhibits PKCα, PKCβ, and PKCγ isoforms, but with significantly reduced potency (IC50 = 30-42 µM). Has reduced inhibitory activity on PKCε, PKCη, and PKCξ (IC50 = 80-100 µM). Also known to inhibit CaM kinase III (IC50 = 5.3 µM).
    FormOrange solid
    CAS number82-08-6
    RTECSAM6913800
    Chemical formulaC₃₀H₂₈O₈
    Structure formulaStructure formula
    Purity≥98% by HPLC
    SolubilityDMSO (30 mg/ml) or Ethanol (1 mg/ml)
    Storage +2°C to +8°C
    Do Not Freeze Ok to freeze
    Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    Toxicity Standard Handling
    Merck USA index14, 8272
    ReferencesVillalba, M., et al. 1999. J. Immunol. 163, 5813.
    Gschwendt, M., et al. 1994. Biochem. Biophys. Res. Commun. 199, 93.
    Gschwendt, M., et al. 1994. FEBS Lett. 338, 85.
    Gschwendt, M., et al. 1984. Cancer Lett. 25, 177.
    Citation
  • Phuong Thi Nguyen Sarkis, et al. (2006) STAT1-independent cell type-specific regulation of antiviral APOBEC3G by IFN-α. Journal of Immunology 177, 4530-4540.
  • Ying Zhang, Mingjuan Liao and Maria L. Dufau. (2006) Phosphatidylinositol 3-kinase/protein kinase Cγ-induced phosphorylation of Sp1 and p107 repressor release have a critical role in histone deacetylase inhibitor-mediated depression of transcription of the luteinizing hormone receptor gene. Molecular and Cellular Biology 26, 6748-6761.
  • Yoon-Jin Lee, et al. (2005) HSP25 inhibits protein kinase Cγ-mediated cell death through direct interaction. Journal of Biological Chemistry 280, 18108-18119.
    		•