553008 Sigma-AldrichRaf1 Kinase Inhibitor I - CAS 220904-83-6 - Calbiochem
The Raf1 Kinase Inhibitor I, also referenced under CAS 220904-83-6, controls the biological activity of Raf1 Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephospho
More>> The Raf1 Kinase Inhibitor I, also referenced under CAS 220904-83-6, controls the biological activity of Raf1 Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Less<<MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: 5-Iodo-3-[(3,5-dibromo-4-hydroxyphenyl)methylene]-2-indolinone, GW 5074
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Overview
Key Spec Table
| CAS # | Empirical Formula |
|---|---|
| 220904-83-6 | C₁₅H₈Br₂INO₂ |
Products
| Catalogue Number | Packaging | Qty/Pack | |
|---|---|---|---|
| 553008-1MG | Plastic ampoule | 1 mg |
| Description | |
|---|---|
| Overview | A potent, cell-permeable, reversible, and ATP-competitive cRAF1 kinase inhibitor (IC50 = 9 nM). Shows ≥100-fold selectivity for Raf kinase versus Cdk1, Cdk2, c-Src, ERK2, MEK, p38, Tie2, VEGFR2, and c-Fms. Predicted broad spectrum antitumor agents. A 10 mM (500 µg/96 µl) solution of Raf1 Inhibitor I (Cat. No. 553003) in DMSO is also available. |
| Catalogue Number | 553008 |
| Brand Family | Calbiochem® |
| Synonyms | 5-Iodo-3-[(3,5-dibromo-4-hydroxyphenyl)methylene]-2-indolinone, GW 5074 |
| References | |
|---|---|
| References | Lackey, K., et al. 2000. Bioorg. Med. Chem. Lett. 10, 223. |
| Product Information | |
|---|---|
| CAS number | 220904-83-6 |
| ATP Competitive | Y |
| Form | Dark orange solid |
| Hill Formula | C₁₅H₈Br₂INO₂ |
| Chemical formula | C₁₅H₈Br₂INO₂ |
| Reversible | Y |
| Structure formula Image | |
| Quality Level | MQ100 |
| Biological Information | |
|---|---|
| Primary Target | CRAFI kinase |
| Primary Target IC<sub>50</sub> | 9 nM |
| Purity | ≥97% by HPLC |
| Physicochemical Information | |
|---|---|
| Cell permeable | Y |
| Packaging Information | |
|---|---|
| Packaged under inert gas | Packaged under inert gas |
| Global Trade Item Number | |
|---|---|
| Catalogue Number | GTIN |
| 553008-1MG | 04055977193404 |