557403 Sigma-AldrichRNA Polymerase III Inhibitor - CAS 577784-91-9 - Calbiochem
RNA Polymerase III Inhibitor, CAS 577784-91-9, is a cell-permeable inhibitor of RNA Polymerase III (IC₅₀ = 27 and 32 µM for human and S. cerevisiae RNA Pol III, respectively).
More>> RNA Polymerase III Inhibitor, CAS 577784-91-9, is a cell-permeable inhibitor of RNA Polymerase III (IC₅₀ = 27 and 32 µM for human and S. cerevisiae RNA Pol III, respectively). Less<<MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: ML-60218, N-[1-(3-(5-Chloro-3-methylbenzo[b]thiophen-2-yl-1-methyl-1H-pyrazol-5-yl)]-2-chlorobenzenesulfonamide
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Overview
Key Spec Table
| CAS # | Empirical Formula |
|---|---|
| 577784-91-9 | C₁₉H₁₅Cl₂N₃O₂S₂ |
Products
| Catalogue Number | Packaging | Qty/Pack | |
|---|---|---|---|
| 557403-10MG | Plastic ampoule | 10 mg |
| Description | |
|---|---|
| Overview | A cell-permeable indazolo-sulfonamide compound that displays broad-spectrum inhibitory activity against RNA Polymerase III (IC50 = 27 and 32 µM for human and S. cerevisiae RNA Pol III, respectively). Inhibits cell growth in yeast by preventing RNA Pol III-mediated tRNA transcription. Also available as a 25 mM solution in DMSO (Cat. No. 557404). |
| Catalogue Number | 557403 |
| Brand Family | Calbiochem® |
| Synonyms | ML-60218, N-[1-(3-(5-Chloro-3-methylbenzo[b]thiophen-2-yl-1-methyl-1H-pyrazol-5-yl)]-2-chlorobenzenesulfonamide |
| References | |
|---|---|
| References | Wu, L., et al. 2003. Euk. Cell 2, 256. |
| Product Information | |
|---|---|
| CAS number | 577784-91-9 |
| ATP Competitive | N |
| Form | Off-white solid |
| Hill Formula | C₁₉H₁₅Cl₂N₃O₂S₂ |
| Chemical formula | C₁₉H₁₅Cl₂N₃O₂S₂ |
| Reversible | N |
| Structure formula Image | |
| Quality Level | MQ100 |
| Biological Information | |
|---|---|
| Primary Target | activity against RNA Polymerase III |
| Primary Target IC<sub>50</sub> | 27 and 32 µM for Human and S. cerevisiae RNA Pol III |
| Purity | ≥95% by HPLC |
| Physicochemical Information | |
|---|---|
| Cell permeable | Y |
| Packaging Information | |
|---|---|
| Packaged under inert gas | Packaged under inert gas |
| Global Trade Item Number | |
|---|---|
| Catalogue Number | GTIN |
| 557403-10MG | 04055977268058 |