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551600 Quercetin, Dihydrate - CAS 6151-25-3 - Calbiochem

551600
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Overview

Key Spec Table

CAS #Empirical Formula
6151-25-3C₁₅H₁₀O₇ · 2H₂O

Products

Catalogue NumberPackaging Qty/Pack
551600-100MG Glass bottle 100 mg
Description
OverviewA cell-permeable and reversible inhibitor of PIM1 kinase (IC50 = 43 nM), PI 3-K (IC50 = 3.8 µM) and phospholipase A2 (IC50 = 2 µM). Also inhibits mitochondrial ATPase, phosphodiesterases, and protein kinase C. Induces apoptosis in K562, Molt-4, Raji, and MCAS tumor cell lines. Reported to activate sirtuins and promote the survival of eukaryotic cells.
Catalogue Number551600
Brand Family Calbiochem®
Synonyms3,3ʹ,4ʹ,5,7-Pentahydroxyflavone
References
ReferencesBullock, A.N., et al. 2005. J. Med. Chem. 48, 7604.
Howitz, K.T., et al. 2003. Nature 425, 191.
Wei, Y.Q., et al. 1994. Cancer Res. 54, 4952.
Shibasaki, F., et al. 1993. Biochem. J. 289, 227.
Matter, W.F., et al. 1992. Biochem. Biophys. Res. Comm. 186, 624.
Levy, J., et al. 1984. Biochem. Biophys. Res. Commun. 123, 1227.
Graziani, Y., et al. 1983. Eur. J. Biochem. 135, 583.
Gschwendt, M., et al. 1983. Biochem. Biophys. Res. Commun. 117, 444.
Ruckstuhl, M., et al. 1979. Biochem. Pharmacol. 28, 535.
Beretz, A., et al. 1978. Experientia 34, 1054.
Product Information
CAS number6151-25-3
ATP CompetitiveN
FormYellow solid
Hill FormulaC₁₅H₁₀O₇ · 2H₂O
Chemical formulaC₁₅H₁₀O₇ · 2H₂O
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Biological Information
Primary TargetPI 3-kinase
Primary Target IC<sub>50</sub>43 nM, 3.8 µM, 2 µM against PIM1 kinase, PI 3-K, and phospholipase A2, respectively
Purity>95% by HPLC
Physicochemical Information
Cell permeableY
Safety Information according to GHS
RTECSLK8950000
Safety Information
R PhraseR: 25-40

Toxic if swallowed.
Limited evidence of a carcinogenic effect.
S PhraseS: 36/37/39-45

Wear suitable protective clothing, gloves and eye/face protection.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Toxic & Carcinogenic / Teratogenic
Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage +15°C to +30°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 3 months at 4°C.
Global Trade Item Number
Catalogue Number GTIN
551600-100MG 07790788051426