540220 Sigma-AldrichPurmorphamine - CAS 483367-10-8 - Calbiochem
A cell-permeable activator of Hedgehog signaling that induces osteoblast differentiation of multipotent mesenchymal progenitor cells C3H10T1/2 (EC₅₀ = 1 µM).
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Synonyms: 2-(1-Naphthoxy)-6-(4-morpholinoanilino)-9-cyclohexylpurine, Shh Signaling Agonist
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Overview
Key Spec Table
| CAS # | Empirical Formula |
|---|---|
| 483367-10-8 | C₃₁H₃₂N₆O₂ |
Products
| Catalogue Number | Packaging | Qty/Pack | |
|---|---|---|---|
| 540220-20MG | Glass bottle | 20 mg | |
| 540220-5MG | Plastic ampoule | 5 mg |
| Description | |
|---|---|
| Overview | A cell-permeable 2,6,9-trisubstituted purine compound that induces osteoblast differentiation of multipotent mesenchymal progenitor cells C3H10T1/2 (EC50 = 1 µM) and lineage-committed preosteoblasts MC3T3-E1. Its effect can be synergized with that of BMP-4 (bone morphogenetic protein-4) and has been shown to induce transdifferentiation even in preadipocytes and myoblasts. Reported to induce osteogenesis by activation of the Hedgehog signaling pathway. A 50 mM (5 mg/192 µl) solution of Purmorphamine (Cat. No. 540223) in DMSO is also available. Please note that the molecular weight for this compound is batch-specific due to variable water content. |
| Catalogue Number | 540220 |
| Brand Family | Calbiochem® |
| Synonyms | 2-(1-Naphthoxy)-6-(4-morpholinoanilino)-9-cyclohexylpurine, Shh Signaling Agonist |
| References | |
|---|---|
| References | Wu, X., et al. 2004. Chem. Biol. 11, 1229. Wu, X., et al. 2002. J. Am. Chem. Soc. 124, 14520. |
| Product Information | |
|---|---|
| CAS number | 483367-10-8 |
| ATP Competitive | N |
| Form | Off-white solid |
| Hill Formula | C₃₁H₃₂N₆O₂ |
| Chemical formula | C₃₁H₃₂N₆O₂ |
| Reversible | N |
| Structure formula Image | |
| Physicochemical Information | |
|---|---|
| Cell permeable | Y |
| Safety Information | |
|---|---|
| R Phrase | R: 22-68 Harmful if swallowed. Possible risks of irreversible effects. |
| S Phrase | S: 22-36/37 Do not breathe dust. Wear suitable protective clothing and gloves. |
| Packaging Information | |
|---|---|
| Packaged under inert gas | Packaged under inert gas |
| Global Trade Item Number | |
|---|---|
| Catalogue Number | GTIN |
| 540220-20MG | 04055977268737 |
| 540220-5MG | 07790788051389 |