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516620 Peroxynitrite - Calbiochem

516620
Purchase on Sigma-Aldrich

Overview

Products

Catalogue NumberPackaging Qty/Pack
516620-1SET Alu drum 1 set
Description
OverviewSynthesized from isoamyl nitrite and hydrogen peroxide. Peroxynitrite (ONOO) is a cell-permeable strong biological oxidizing agent that reacts with DNA, membrane phospholipids, sulfhydryl groups, and tyrosine. Has been implicated in a variety of pathophysiological conditions including acute respiratory distress syndrome (ARDS), arthritis, atherosclerosis, inflammatory bowel disease, ischemia-reperfusion, N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-mediated neurotoxicity, and septic shock.
Note: 1 set = 2 x 1 ml.
Catalogue Number516620
Brand Family Calbiochem®
References
ReferencesMarla, S.S., et al. 1997. Proc. Natl. Acad. Sci. USA 94, 14243.
Sakuma, S., et al. 1997. Biochem. Biophys. Res. Commun. 230, 476.
Lymar, S.V., et al. 1996. Biochemistry 35, 7855.
Uppu, R.M., and Pryor, W.A. 1996. Methods Enzymol. 269, 322.
Ischiropoulos, H., and al-Medhi, A.B. 1995. FEBS Lett. 364, 279.
Product Information
ATP CompetitiveN
FormYellow liquid
FormulationSupplied in 4.7% NaOH at 160-200 mM.
ReversibleN
Quality LevelMQ100
Applications
ApplicationPeroxynitrite, CAS 14042-01-4, is a cell-permeable, short-lived, strong biological oxidant agent that reacts with and can damage DNA, membrane phospholipids, sulfhydryl groups, and tyrosine.
Biological Information
Primary TargetOxidizing agent that reacts with DNA, membrane phospholipids, sulfhydryl groups, and tyrosine
Physicochemical Information
Cell permeableY
Safety Information
R PhraseR: 8-20/22-34

Contact with combustible material may cause fire.
Harmful by inhalation and if swallowed.
Causes burns.
S PhraseS: 3-28-36/37/39-45

Keep in a cool place.

Wear suitable protective clothing, gloves and eye/face protection.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Storage and Shipping Information
Ship Code Dry Ice Only
Toxicity Oxidizer
Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage ≤ -70°C
Protect from Light Protect from light
Avoid freeze/thaw Avoid freeze/thaw
Do not freeze Ok to freeze
Special InstructionsProtect from heat, light, metal ions, and air. Peroxynitrite is unstable; thaw rapidly, dispense into aliquots, purge tubes with an inert gas, and freeze -70°C. Activity decreases ~2% /day at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Catalogue Number GTIN
516620-1SET 04055977198256