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521233 PDGFR Tyrosine Kinase Inhibitor IV - CAS 627518-40-5 - Calbiochem

521233
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Overview

Key Spec Table

CAS #Empirical Formula
627518-40-5C₁₈H₁₆FN₃O₂

Products

Catalogue NumberPackaging Qty/Pack
521233-1MG Plastic ampoule 1 mg
Description
OverviewA cell-permeable indenopyrazole compound that displays potent antiproliferative properties in several human tumor cell lines (IC50 < 33 nM). Shown to act as an ATP-competitive and reversible inhibitor of PDGFR (IC50 = 4.2 nM and 45 nM for -β and -α, respectively) and c-Abl (IC50 = 22 nM). Exhibits less activity towards Lck, c-Src, and Fyn (IC50 = 100 nM, 185 nM and 378 nM, respectively) and exhibits little or no inhibition toward VEGFR, HER-2, Cdk's-1,-2,-4 &-7, bFGFR-1 and EGFR (IC50 = 3.1 µM, > 10 µM, > 10 µM, 45.8 µM and > 100 µM, respectively).
Catalogue Number521233
Brand Family Calbiochem®
Synonyms3-Fluoro-N-(6,7-dimethoxy-2,4-dihydroindeno[1,2-c]pyrazol-3-yl)phenylamine, JNJ-10198409
References
ReferencesHo, C.Y., et al. 2005. J. Med. Chem. 48, 8163.
Product Information
CAS number627518-40-5
ATP CompetitiveY
FormOff-white solid
Hill FormulaC₁₈H₁₆FN₃O₂
Chemical formulaC₁₈H₁₆FN₃O₂
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Biological Information
Primary TargetPDGFR Tyrosine Kinase
Primary Target IC<sub>50</sub>4.2 nM and 45 nM for -β and -α form of PDGFR, respectively
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Harmful
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Catalogue Number GTIN
521233-1MG 04055977271379