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14-700 NEK11 Protein, active, 10 µg

Active, 6His-tagged, recombinant, human full length, NEK11, for use in Kinase Assays.

NEK11 Protein, active, 10 µg MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
14-700
10 µg  
Purchase on Sigma-Aldrich

Overview

Replacement Information
Description
Catalogue Number14-700
Brand Family Upstate
Trade Name
  • Upstate
DescriptionNEK11 Protein, active, 10 µg
Overview6His-tagged, recombinant, human full length, NEK11
References
Product Information
Quality LevelMQ100
Applications
ApplicationActive, 6His-tagged, recombinant, human full length, NEK11, for use in Kinase Assays.
Key Applications
  • Kinase Assay
Biological Information
Sourceexpressed by baculovirus in Sf21 cells
Specific ActivityFor Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Entrez Gene Number
Entrez Gene SummaryNEK11 belongs to the NIMA family of kinases, which are involved in DNA replication and genotoxic stress responses (Noguchi et al., 2002 [PubMed 12154088]).[supplied by OMIM]
Gene Symbol
  • NEK11
  • FLJ23495
Protein TargetNEK11
Purification MethodNi2+/NTA-agarose
Target Sub-FamilyMisc
UniProt Number
UniProt SummaryFUNCTION: SwissProt: Q8NG66 # Possible role in S-phase checkpoint mechanism.
COFACTOR: Manganese or magnesium.
SIZE: 645 amino acids; 74162 Da
SUBCELLULAR LOCATION: Nucleus. Nucleus, nucleolus. Note=Nuclear during interphase but moves to the polar microtubules during prometaphase and metaphase. Accumulates in the nucleolus in G1/S- arrested cells.
TISSUE SPECIFICITY: Poorly expressed in cerebellum, trachea, lung, appendix, and uterus.
DEVELOPMENTAL STAGE: Predominantly expressed at S/G2/M phase.
PTM: Phosphorylated.
SIMILARITY: SwissProt: Q8NG66 ## Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. NIMA subfamily. & Contains 1 protein kinase domain.
Molecular Weight59.3kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assuranceroutinely evaluated by phosphorylation of MBP (Catalog # 13-104)
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions6 months at -70°C from date of shipment
Packaging Information
Material Size10 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
14-700 04053252282324