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14-690M MLK1 Protein, active, 250 µg

Active, N-terminal 6His-tagged, recombinant, human MLK1, amino acids 134-414, for use in Kinase Assays.

14-690M
250 µg  Also available in 10 μg size (cat#14-690) and in bulk (cat#14-690-K).
Purchase on Sigma-Aldrich

Overview

Replacement Information
Description
Catalogue Number14-690M
Brand Family Upstate
Trade Name
  • Upstate
DescriptionMLK1 Protein, active, 250 µg
OverviewN-terminal 6His-tagged, recombinant, human MLK1, amino acids 134-414
References
Product Information
Quality LevelMQ300
Applications
ApplicationActive, N-terminal 6His-tagged, recombinant, human MLK1, amino acids 134-414, for use in Kinase Assays.
Key Applications
  • Kinase Assay
Biological Information
Sourceexpressed by baculovirus in Sf21 cells
Entrez Gene Number
Gene Symbol
  • MAP3K9
  • MLK1
  • PRKE1
Protein TargetMLK1
Purification MethodNi2+/NTA-agarose
Target Sub-FamilyTKL
UniProt Number
UniProt SummaryFUNCTION: SwissProt: P80192 # Activates the JUN N-terminal pathway.
COFACTOR: Magnesium.
SIZE: 1104 amino acids; 121895 Da
SUBUNIT: Homodimer (By similarity).
TISSUE SPECIFICITY: Expressed in epithelial tumor cell lines of colonic, breast and esophageal origin.
PTM: Autophosphorylation on serine and threonine residues within the activation loop plays a role in enzyme activation. Thr-312 is likely to be the main autophosphorylation site.
SIMILARITY: SwissProt: P80192 ## Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. & Contains 1 protein kinase domain. & Contains 1 SH3 domain.
Molecular Weight35.3kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceRoutinely evaluated by phosphorylation of Casein
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions6 months at -70°C from date of shipment
Packaging Information
Material Size250 µg
Material PackageAlso available in 10 μg size (cat#14-690) and in bulk (cat#14-690-K).
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
14-690M 04053252925344

Documentation

Related Products & Applications

Alternative Packsize

Catalogue Number Description
14-690 MLK1 Protein, active, 10 µg

Product Families

Kinase & Phosphatase Products

Millipore offers a large portfolio of Kinases, Phophatases, Substrates, Inhibitors, Kits, reagents & tools for Signaling research. See below for a list of these products, in multiple pack sizes.
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Categories

Life Science Research > Proteins and Enzymes > Purified Kinases
Life Science Research > Drug Discovery and Development > Kinase & Phosphatase Screening > Purified Kinases