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438186 Lovastatin, Sodium Salt - Calbiochem

Carboxylate form of Lovastatin that is active in whole cells and cell-free assays.

Lovastatin, Sodium Salt - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: L-Type Calcium Channel Blocker IV

Primary Target: 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase
438186
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₂₄H₃₇O₆ • Na

Products

Catalogue NumberPackaging Qty/Pack
438186-5MG Plastic ampoule 5 mg
Description
OverviewCarboxylate form of Lovastatin (Cat. No. 438185) that is active in whole cells and cell-free assays.
Catalogue Number438186
Brand Family Calbiochem®
SynonymsL-Type Calcium Channel Blocker IV
References
ReferencesRao, S., et al. 1999. Proc. Natl. Acad. Sci. USA 96, 7197.
Carel, K., et al. 1996. J. Biol. Chem. 271, 30625.
McGuire, T.F., et al. 1996. J. Biol. Chem. 271, 27402.
Umetani, N., et al. 1996. Biochim. Biophys. Acta 1303, 199.
Xu, X.Q., et al. 1996. Arch. Biochem. Biophys. 326, 233.
Reusch, J.E.-B., et al. 1995. J. Biol. Chem. 270, 2036.
Product Information
ATP CompetitiveN
FormOff-white solid
Hill FormulaC₂₄H₃₇O₆ • Na
Chemical formulaC₂₄H₃₇O₆ • Na
Hygroscopic Hygroscopic
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ200
Applications
Biological Information
Primary Target3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Carcinogenic / Teratogenic
Storage -20°C
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot, flush with an inert gas, and freeze (-20°C). Stock solutions in high quality ethanol are stable for up to 1 month at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
438186-5MG 07790788050276

Documentation

Lovastatin, Sodium Salt - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Lovastatin, Sodium Salt - Calbiochem Certificates of Analysis

TitleLot Number
438186

References

Reference overview
Rao, S., et al. 1999. Proc. Natl. Acad. Sci. USA 96, 7197.
Carel, K., et al. 1996. J. Biol. Chem. 271, 30625.
McGuire, T.F., et al. 1996. J. Biol. Chem. 271, 27402.
Umetani, N., et al. 1996. Biochim. Biophys. Acta 1303, 199.
Xu, X.Q., et al. 1996. Arch. Biochem. Biophys. 326, 233.
Reusch, J.E.-B., et al. 1995. J. Biol. Chem. 270, 2036.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision06-August-2008 RFH
SynonymsL-Type Calcium Channel Blocker IV
DescriptionCarboxylate form of Lovastatin (Cat. No. 438185) that is active in whole cells and cell-free assays. Lovastatin is reported to be an anti-hypercholesterolemic agent that acts as an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase and blocks a series of biological events including activation of p21ras by insulin in 3T3-L1 fibroblasts and 3T3-L1 adipocytes, farnesylation of p21ras, which decreases the pool of intracellular Ras available for subsequent activation by growth factors (including insulin), and N-ras-induced neuronal differentiation. Causes cell cycle arrest in the late G1 phase. Shown to inhibit the stimulation of MAP kinase by insulin in HIRcB cells and block the transcription of the type-I SCR gene in THP-1-derived macrophages. Also blocks PDGF receptor tyrosine phosphorylation and MAP kinase activation by PDGF.
FormOff-white solid
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₂₄H₃₇O₆ • Na
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (100 mg/ml) or Ethanol (50 mg/ml)
Storage -20°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot, flush with an inert gas, and freeze (-20°C). Stock solutions in high quality ethanol are stable for up to 1 month at -20°C.
Toxicity Carcinogenic / Teratogenic
ReferencesRao, S., et al. 1999. Proc. Natl. Acad. Sci. USA 96, 7197.
Carel, K., et al. 1996. J. Biol. Chem. 271, 30625.
McGuire, T.F., et al. 1996. J. Biol. Chem. 271, 27402.
Umetani, N., et al. 1996. Biochim. Biophys. Acta 1303, 199.
Xu, X.Q., et al. 1996. Arch. Biochem. Biophys. 326, 233.
Reusch, J.E.-B., et al. 1995. J. Biol. Chem. 270, 2036.