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540218 LYP Inhibitor II, LTV-1 - Calbiochem

The LYP Inhibitor II, LTV-1 controls the biological activity of LYP. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

LYP Inhibitor II, LTV-1 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: (E)-3-((4-((4,6-Dioxo-2-thioxo-1-o-tolyltetrahydropyrimidin-5(6H)-ylidene)methyl)phenoxy)methyl)benzoic acid, Lymphoid Tyrosine Phosphatase Inhibitor II, LTV-1

Primary Target: LYP
540218
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Overview

Key Spec Table

Empirical Formula
C₂₆H₂₀N₂O₅S

Products

Catalogue NumberPackaging Qty/Pack
540218-10MG Glass bottle 10 mg
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Description
OverviewA cell-permeable thiobarbituryl-benzoate compound that acts as a highly potent and reversible inhibitor of lymphoid tyrosine phosphatase (LYP) (IC50 = 508 nM) and thereby enhances TCR signaling in intact cells. Exhibits competitive to mixed mode of inhibition (Ki = 384 nM). Also shown to inhibit the mutant, disease associated LYP-Trp620 activity. Binds to the phosphate-binding loop and mimicks the phosphotyrosine moiety of substrates. Displays acceptable selectivity over a wide range of protein phosphatases (TCPTP, PTP1B, PEP (mouse LYP), SHP1, CD45 and PTP-PEST: IC50 = 1.52, 1.59, 7.56, 23.2, 30.1, and 100 µM, respectively). Does not exhibit any toxicity at pharmacological doses when tested in primary human cell lines.
Catalogue Number540218
Brand Family Calbiochem®
Synonyms(E)-3-((4-((4,6-Dioxo-2-thioxo-1-o-tolyltetrahydropyrimidin-5(6H)-ylidene)methyl)phenoxy)methyl)benzoic acid, Lymphoid Tyrosine Phosphatase Inhibitor II, LTV-1
References
ReferencesVang, T., et al. 2012. Nat. Chem. Biol. 8, 437.
Product Information
FormOrange powder
Hill FormulaC₂₆H₂₀N₂O₅S
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Biological Information
Primary TargetLYP
Primary Target IC<sub>50</sub>508 nM for LYP
Secondary targetOthet PTPases
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C>
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Catalogue Number GTIN
540218-10MG 04055977268720