440202 Sigma-AldrichLY 294002 - CAS 154447-36-6 - Calbiochem
LY294002, CAS 154447-36-6, is a cell-permeable, potent, reversible, and specific inhibitor of PI 3-kinase ((IC₅₀ = 1.4 µM). Acts on the ATP-binding site.
More>> LY294002, CAS 154447-36-6, is a cell-permeable, potent, reversible, and specific inhibitor of PI 3-kinase ((IC₅₀ = 1.4 µM). Acts on the ATP-binding site. Less<<LY 294002 - CAS 154447-36-6 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: 2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one, BRD2 Inhibitor IV, BRD3 Inhibitor III, BRD4 Inhibitor IV
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Overview
Key Spec Table
| CAS # | Empirical Formula |
|---|---|
| 154447-36-6 | C₁₉H₁₇NO₃ |
Products
| Catalogue Number | Packaging | Qty/Pack | |
|---|---|---|---|
| 440202-10MG | Plastic ampoule | 10 mg | |
| 440202-25MG | Plastic ampoule | 25 mg | |
| 440202-5MG | Plastic ampoule | 5 mg |
| Description | |
|---|---|
| Overview | A cell-permeable, potent, reversible and specific phosphatidylinositol 3-kinase inhibitor (IC50 = 1.4 µM) that acts on the ATP-binding site of the enzyme. Also inhibits nonhomologous DNA end-joining (NHEJ) activity of the 460 kDa phosphatidylinositol 3-like kinase DNA-PKcs, which is the catalytic subunit of DNA-activated protein kinase. Does not affect the activities of EGF receptor kinase, MAP kinase, PKC, Pl 4-kinase, S6 kinase, and c-Src even at 50 µM. Promotes the nuclear accumulation of active GSK-3b. Reported to suppress the proliferation of murine embryonic stem cells. Blocks the proliferation of cultured rabbit aortic smooth muscle cells without inducing apoptosis. Shown to bind to the same site as I-BET (Cat. No. 40101050 ~ 10 µM). A 10 mM (1 mg/325 µl) solution of LY 294002 (Cat. No. 440204) in DMSO is also available. |
| Catalogue Number | 440202 |
| Brand Family | Calbiochem® |
| Synonyms | 2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one, BRD2 Inhibitor IV, BRD3 Inhibitor III, BRD4 Inhibitor IV |
| References | |
|---|---|
| References | Dittman, A., et al. 2013. ACS Chem. Biol. 9, 495. Bechard, M., and Dalton. S. 2009. Mol. Cell. Biol. 29, 2092. Lianguzova, M.S. et al. 2007. Cell Biol. Int. 31, 330. Baumann, P., and West, S.C. 1998. Proc. Natl. Acad. Sci. USA 95, 14066. Cardone, M.H., et al. 1998. Science 282, 1318. Vlahos, C.J., et al. 1995. J. Immunol. 154, 2413. Yano, H., et al. 1995. Biochem. J. 312, 145. Vlahos, C.J., et al. 1994. J. Biol. Chem. 269, 5241. Selected Citations Lee, J., et al. 2009. Cell Stem Cell 5, 76. |
| Product Information | |
|---|---|
| CAS number | 154447-36-6 |
| ATP Competitive | Y |
| Form | Off-white solid |
| Hill Formula | C₁₉H₁₇NO₃ |
| Chemical formula | C₁₉H₁₇NO₃ |
| Reversible | Y |
| Structure formula Image | |
| Quality Level | MQ100 |
| Biological Information | |
|---|---|
| Primary Target | Phosphatidylinositol 3-kinase |
| Primary Target IC<sub>50</sub> | 1.4 µM against phosphatidylinositol 3-kinase |
| Purity | ≥98% by HPLC |
| Physicochemical Information | |
|---|---|
| Cell permeable | Y |
| Global Trade Item Number | |
|---|---|
| Catalogue Number | GTIN |
| 440202-10MG | 04055977186666 |
| 440202-25MG | 04055977186673 |
| 440202-5MG | 07790788050290 |