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420320 KT5720 - CAS 108068-98-0 - Calbiochem

KT5720, CAS 108068-98-0, is a cell-permeable, potent, specific, reversible, ATP-competitive inhibitor of protein kinase A (Ki = 56 nM). Has no significant effect on PKC, PKG & MLCK.

KT5720 - CAS 108068-98-0 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: PKA Inhibitor VII

Primary Target: PKA
420320
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
108068-98-0C₃₂H₃₁N₃O₅

Products

Catalogue NumberPackaging Qty/Pack
420320-100UG Glass bottle 100 μg
420320-50UG Plastic ampoule 50 μg
Description
OverviewA potent, specific, cell-permeable, reversible and ATP-competitive inhibitor of protein kinase A (Ki = 56 nM) that is prepared by a chemical modification of K-252a. Does not significantly affect the activities of PKC, PKG, and MLCK. Inhibits axon branching in cultured neurons. A 2 mM (50 µg/47 µl) solution of KT 5720 (Cat. No. 420323) in DMSO is also available.
Catalogue Number420320
Brand Family Calbiochem®
SynonymsPKA Inhibitor VII
References
ReferencesSimpson, C.S., and Morris, B.J. 1995. Neuroscience 68, 97.
Cabell, L., and Audesirk, G. 1993. Int. J. Dev. Neurosci. 11, 357.
Gadbois, D.M., et al. 1992. Proc. Natl. Acad. Sci. USA 89, 8626.
Kase, H., et al. 1987. Biochem. Biophys. Res. Commun. 142, 436.
Product Information
CAS number108068-98-0
ATP CompetitiveY
FormWhite solid
Hill FormulaC₃₂H₃₁N₃O₅
Chemical formulaC₃₂H₃₁N₃O₅
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationKT5720, CAS 108068-98-0, is a cell-permeable, potent, specific, reversible, ATP-competitive inhibitor of protein kinase A (Ki = 56 nM). Has no significant effect on PKC, PKG & MLCK.
Biological Information
Primary TargetPKA
Primary Target K<sub>i</sub>56 nM for protein kinase A
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
420320-100UG 04055977211023
420320-50UG 04055977211030

Documentation

KT5720 - CAS 108068-98-0 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

KT5720 - CAS 108068-98-0 - Calbiochem Certificates of Analysis

TitleLot Number
420320

References

Reference overview
Simpson, C.S., and Morris, B.J. 1995. Neuroscience 68, 97.
Cabell, L., and Audesirk, G. 1993. Int. J. Dev. Neurosci. 11, 357.
Gadbois, D.M., et al. 1992. Proc. Natl. Acad. Sci. USA 89, 8626.
Kase, H., et al. 1987. Biochem. Biophys. Res. Commun. 142, 436.

Citations

Title
  • Mike T. Lin, et al. (2005) Ca2+-activated K+ channel-associated phosphatase and kinase activities during development. American Journal of Physiology Heart and Circulatory Physiology 289, H414-H425.
    		•
    Data Sheet

    Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

    Revision08-January-2010 RFH
    SynonymsPKA Inhibitor VII
    DescriptionPrepared by a chemical modification of K-252a. A potent, specific, cell-permeable, reversible and ATP-competitive inhibitor of protein kinase A (Ki = 56 nM). Does not significantly affect the activity of PKC, PKG, or MLCK. Inhibits axon branching in cultured neurons.
    FormWhite solid
    CAS number108068-98-0
    Chemical formulaC₃₂H₃₁N₃O₅
    Structure formulaStructure formula
    Purity≥95% by HPLC
    SolubilityDMSO (1 mg/ml). Further dilute with aqueous buffers just prior to use.
    Storage Protect from light
    -20°C
    Do Not Freeze Ok to freeze
    Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
    Toxicity Standard Handling
    ReferencesSimpson, C.S., and Morris, B.J. 1995. Neuroscience 68, 97.
    Cabell, L., and Audesirk, G. 1993. Int. J. Dev. Neurosci. 11, 357.
    Gadbois, D.M., et al. 1992. Proc. Natl. Acad. Sci. USA 89, 8626.
    Kase, H., et al. 1987. Biochem. Biophys. Res. Commun. 142, 436.
    Citation
  • Mike T. Lin, et al. (2005) Ca2+-activated K+ channel-associated phosphatase and kinase activities during development. American Journal of Physiology Heart and Circulatory Physiology 289, H414-H425.
    		•