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420116 JNK Inhibitor I, (L)-Form, Cell-Permeable - Calbiochem

JNK Inhibitor I, (L)-Form, Cell-Permeable peptide with a C-terminal sequence from the JNK-binding domain and an N-terminal peptide with HIV-TAT48-57 sequence. Blocks c-jun activation (IC50&n

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Synonyms: (L)-JNKI1, (L)-HIV-TAT₄₈₋₅₇-PP-JBD₂₀, H-GRKKRRQRRRPPRPKRPTTLNLFPQVPRSQDT-NH₂, c-Jun NH₂-terminal kinase, SAPK Inhibitor I

Primary Target: JNK
420116
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Overview

Key Spec Table

Empirical Formula
C₁₆₈H₂₉₃N₆₇O₄₂

Products

Catalogue NumberPackaging Qty/Pack
420116-1MG Plastic ampoule 1 mg
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Description
OverviewA cell-permeable, biologically active peptide consisting of a carboxyl terminal sequence derived from the JNK-binding domain (JBD) and an amino terminal peptide containing the HIV-TAT48-57 sequence. Blocks c-Jun NH2-terminal kinase (JNK) signaling by preventing the activation of the transcription factor c-jun (IC50 ~ 1 µM). This effect appears to be due to inhibition of phosphorylation of the activation domains of JNK. Contains the minimal 20-amino acid inhibitory domain of islet-brain (IB) that is shown to be critical for interaction with JNK linked to the 10-amino acid HIV-TAT48-57 sequence as a carrier peptide and two proline residues as spacer. Inhibits IL-1β-induced c-jun and c-fos expression in insulin secreting βTC-3 cells and offers protection against apoptosis. Does not affect insulin secretion and has no effect on either ERK 1/2 or p38 activities.
Catalogue Number420116
Brand Family Calbiochem®
Synonyms(L)-JNKI1, (L)-HIV-TAT₄₈₋₅₇-PP-JBD₂₀, H-GRKKRRQRRRPPRPKRPTTLNLFPQVPRSQDT-NH₂, c-Jun NH₂-terminal kinase, SAPK Inhibitor I
References
ReferencesBarr, R.K., et al. 2002. J. Biol. Chem. 277, 10987.
Bonny, C., et al. 2001. Diabetes 50, 77.
Product Information
ATP CompetitiveN
DeclarationSold under license of U.S. Patents 6,043,083 and 6,410,693.
FormWhite lyophilized solid
FormulationSupplied as a trifluoroacetate salt.
Hill FormulaC₁₆₈H₂₉₃N₆₇O₄₂
Chemical formulaC₁₆₈H₂₉₃N₆₇O₄₂
Hygroscopic Hygroscopic
ReversibleN
Quality LevelMQ100
Applications
ApplicationJNK Inhibitor I, (L)-Form, Cell-Permeable peptide with a C-terminal sequence from the JNK-binding domain and an N-terminal peptide with HIV-TAT48-57 sequence. Blocks c-jun activation (IC50 ~ 1 µM).
Biological Information
Primary TargetJNK
Primary Target IC<sub>50</sub>1 µM
Purity≥97% by HPLC
Physicochemical Information
Cell permeableY
Peptide SequenceH-Gly-Arg-Lys-Lys-Arg-Agr-Gln-Arg-Arg-Arg-Pro-Pro-Arg-Pro-Lys-Arg-Pro-Thr-Thr-Leu-Asn-Leu-Phe-Pro-Gln-Val-Pro-Arg-Ser-Gln-Asp-Thr-NH₂
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Catalogue Number GTIN
420116-1MG 04055977187946