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400046 Hydroxyurea - CAS 127-07-1 - Calbiochem

400046
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Overview

Key Spec Table

CAS #Empirical Formula
127-07-1CH₄N₂O₂

Products

Catalogue NumberPackaging Qty/Pack
400046-5GM Plastic ampoule 5 gm
Description
OverviewAnti-neoplastic agent that blocks DNA replication by inhibiting ribonucleotide reductase. Induces apoptosis in chronic myelogenous leukemia lymphocytes. Reported to enhance the radiation effects in pancreatic adenocarcinoma cells. Releases NO in the presence of oxidizing agents.
Catalogue Number400046
Brand Family Calbiochem®
SynonymsRibonucleotide Reductase Inhibitor I, RNR Inhibitor I
References
ReferencesLeyden, D., et al. 2000. Anticancer Res. 20, 133.
Tsuchiya, K., et al. 1999. Free Radic. Biol. Med. 27, 347.
Anand, S., et al. 1995. Cancer Lett. 88, 101.
Product Information
CAS number127-07-1
ATP CompetitiveN
FormWhite solid
Hill FormulaCH₄N₂O₂
Chemical formulaCH₄N₂O₂
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Biological Information
Primary TargetInhibiting ribonucleotide reductase
Purity≥98% by HPLC
Physicochemical Information
Cell permeableN
Safety Information according to GHS
RTECSYT4900000
Safety Information
R PhraseR: 46-61

May cause heritable genetic damage.
May cause harm to the unborn child.
S PhraseS: 45-53

In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Avoid exposure - obtain special instructions before use.
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Carcinogenic / Teratogenic
Storage +2°C to +8°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 2 months at 4°C.
Global Trade Item Number
Catalogue Number GTIN
400046-5GM 04055977212129