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344827 Fucosyltransferase Inhibitor, 2F-Peracetyl-Fucose - Calbiochem

344827
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Overview

Key Spec Table

Empirical Formula
C₁₂H₁₇FO₇

Products

Catalogue NumberPackaging Qty/Pack
344827-10MG Glass bottle 10 mg
Description
OverviewA cell-permeable fluorinated fucose derivative that acts as an inhibitor of fucosyltransferases following its uptake and metabolic transformation into a GDP-fucose mimetic. Treatment of HL-60 cells with this inhibitor shows complete abolition of Lewis-X and SLex within 3 days. Also abolishes P-selectin binding and exhibits faster rolling cells on E-selectin and P-selectin coated surfaces. Does not affect cell viability or their doubling time even at 200 µM levels.
Catalogue Number344827
Brand Family Calbiochem®
Synonyms(3S,4R,5R,6S)-3-fluoro-6-methyltetrahydro-2H-pyran-2,4,5-triyl triacetate
References
ReferencesRillahan, C., et al. 2012.. Nat. Chem. Bio. 8, 661.
Product Information
FormWhite solid
Hill FormulaC₁₂H₁₇FO₇
Chemical formulaC₁₂H₁₇FO₇
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ300
Biological Information
Primary TargetFucosyltransferase
Purity≥98% by NMR
Physicochemical Information
Cell permeableY
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Catalogue Number GTIN
344827-10MG 04055977214833